Clinical Analysis of MALT Lymphoma in the Stomach

Paik, Kwang Yeol; Noh, Jae Hyung; Heo, Jin Seok; Sohn, Tae Sung; Choi, Seong Ho; Joh, Jae Won; Kim, Yong Il

Abstract

PURPOSE: The aim of this study was to analyze the clinical and the histopathological characteristics of mucosa associated lymphoid tissue (MALT) lymphomas in the stomach. MATENRIALS AND METHODS: We retrospectively reviewed the medical records of 22 patients who had been treated at Samsung Medical Center from Jan. 1995 to Sep. 2000 and who had been pathologically proven to have a MALT lymphoma. The factors we analyzed were operative procedure, tumor stage, and histopathological characteristics.
RESULTS
Of 3658 patients with a gastric malignancy, 22 patients proved to have a MALT lymphoma (0.6%). There were 7 men and 15 women whose ages ranged from 25 years to 70 years (mean, 48.8 years). Forteen cases were located in the antrum, 4 (18%) in the body and 4 (18%) in the fundus or the high body. Nineteen of these patients were managed with total gastrectomy and splenectomy and 3 with radical subtotal gastrectomy. Histopathologically the tumor was limited to the mucosa in 3 patients (13.6%), to the submucosa in 13 (59.1%) and extended to the muscularis propria in 6 (27.3%). Lymph node involvement was seen in 12 patients (54.6%). There was no splenic or hepatic involvement. Bone marrow involvement was not seen in any patients. H. pylori was identified in 11 patients (50%). During the mean follow-up period of 32.7 months, there were no reports of tumor recurrence or death.
CONCLUSION
MALT lymphomas rarely disseminate by the time of diagnosis and rarely involve the bone marrow. Lymph node involvement is relatively high and a total gastrectomy is effective in managing patients with a MALT lymphoma.