J Gastric Cancer.  2014 Jun;14(2):135-137.

Gastric Adenocarcinoma with Prostatic Metastasis

• Roshni S
• Anoop TM
• Preethi TR
• Shubanshu
• Lijeesh AL

Abstract

Metastasis of gastric adenocarcinoma to the prostate gland is extremely rare. Herein, we report a case of gastric adenocarcinoma in a 56-year-old man with prostatic metastasis diagnosed through the analysis of biopsy specimens from representative lesions in the stomach and prostate gland. Immunohistochemistry of the prostatic tissue showed positive staining for cytokeratin 7 and negative staining for prostate-specific antigen (PSA), whereas the serum PSA level was normal, confirming the diagnosis of prostatic metastasis from carcinoma of the stomach.

Keyword

Stomach neoplasms; Adenocarcinoma; Prostatic secondaries

MeSH Terms

Adenocarcinoma*
Biopsy
Diagnosis
Humans
Immunohistochemistry
Keratin-7
Middle Aged
Negative Staining
Neoplasm Metastasis*
Prostate
Prostate-Specific Antigen
Stomach
Stomach Neoplasms
Keratin-7
Prostate-Specific Antigen

Figure

• 

  Fig. 1 (A) Computed tomography of the abdomen and pelvis showing mural wall thickening involving the gastroesophageal junction and extending to the lesser curvature of the stomach. (B) Computed tomography of the abdomen and pelvis with arrow showing an enlarged prostatic mass.

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  Fig. 2 (A) Upper gastrointestinal endoscopy showing an ulceroinfiltrative growth at the gastroesophageal junction along the lesser curvature of the stomach. (B) Histopathology slides (H&E, ×200) showing moderate-to-poorly differentiated gastric adenocarcinoma with gastric mucosa and ulceration, and cells arranged in a glandular pattern, signet ring cells, and pools of mucin.

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  Fig. 3 (A) Tru-cut biopsy slides (H&E, ×200) of the prostate gland showing infiltration by small and large glands, lined by tall columnar/cuboidal mucinous cells. (B) Immunohistochemical analysis (×400) of prostatic tissue showing cytokeratin 7 positivity. (C) Immunohistochemical analysis (×400) of prostatic tissue showing prostate-specific antigen negativity.

Reference

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4. Epstein JI. PSA and PAP as immunohistochemical markers in prostate cancer. Urol Clin North Am. 1993; 20:757–770.