J Korean Ophthalmol Soc.  2017 Mar;58(3):296-304. 10.3341/jkos.2017.58.3.296.

Comparison of Choroidal Thickness Change between Ranibizumab and Aflibercept in Age-related Macular Degeneration: Six Month Results

• Kim IG
• Kim YI
• Kim JS
• Lee JH
• Lee KW
• Kang HG

• KMID: 2371910
• DOI: http://doi.org/10.3341/jkos.2017.58.3.296

Abstract

PURPOSE
To compare the changes in subfoveal choroidal thickness between intravitreal aflibercept and ranibizumab injection in wet age-related macular degeneration (AMD).
METHODS
Fifty patients with wet AMD patients who were treated with aflibercpet or ranibizumab were evaluated retrospectively. All patients were treated with pro re nata after 3 consecutive monthly injections and were followed up for at least 6 months. We measured subfoveal choroidal thickness (SFCT) using enhanced depth imaging spectral-domain optical coherence tomography before the first injection and 1, 2, 3, and 6 months after initial injection.
RESULTS
The SFCT measures before initial injection and 1, 2, 3, and 6 months after initial injection were 244.94 ± 103.77 µm, 219.04 ± 95.89 µm, 208.74 ± 91.03 µm, 203.64 ± 91.35 µm, and 226.98 ± 96.79 µm in the aflibercept group (25 eyes) and 222.68 ± 102.04 µm, 210.23 ± 95.91 µm, 203.66 ± 99.39 µm, 197.27 ± 100.25 µm, and 210.32 ± 111.86 µm in the ranibizumab group (28 eyes). Mean change in SFCT was greater in the aflibercept group at 1 month, 2 months, and 3 months after initial injection (p < 0.05), but there was no significant difference in the mean change in SFCT between the two groups at 6 months after initial injection (p > 0.05).
CONCLUSIONS
The decrease in SFCT was greater after aflibercept injection than ranibizumab injection in 3 consecutive months. However, at 6 months after initial injection, the difference in the change in SFCT was not significant.

Keyword

Aflibercept; Polypoidal choroidal vasculopathy; Ranibizumab; Subfoveal choroidal thickness; Wet age-related macular degeneration

MeSH Terms

Choroid*
Humans
Macular Degeneration*
Ranibizumab*
Retrospective Studies
Tomography, Optical Coherence
Ranibizumab

Figure

• 

  Figure 1. Changes in best corrected visual acuity (BCVA), intraocular pressure (IOP), central macular thickness (CMT), subfoveal choroidal thickness (SFCT) after aflibercept injection. (A) BCVA was not changed significantly during the follow-up period com-pared with baseline. (B) IOP was decreased significantly 1, 2 months after aflibercept injection compared with baseline. (C) CMT was decreased significantly during the follow-up period compared with baseline. (D) SFCT was decreased significantly 1, 2 and 3 months after aflibercept injection compared with baseline. ETDRS = Early Treatment Diabetic Retinopathy Study. * Compared with baseline by repeated measure analysis of variance (ANOVA), p < 0.05.

• 

  Figure 2. Changes in best corrected visual acuity (BCVA), intraocular pressure (IOP), central macular thickness (CMT), subfoveal choroidal thickness (SFCT) after ranibizumab injection. (A) BCVA was not changed significantly during the follow-up period com-pared with baseline. (B) IOP was not changed significantly during the follow-up period compared with baseline. (C) CMT was de-creased significantly during the follow-up period compared with baseline. (D) SFCT was decreased significantly 1, 2 and 3 months after ranibizumab injection compared with baseline. ETDRS = Early Treatment Diabetic Retinopathy Study. * Compared with base-line by repeated measure analysis of variance (ANOVA), p < 0.05.

• 

  Figure 3. Mean change in subfoveal choroidal thickness in aflibercept injection and ranibizumab injection. Subfoveal choroidal thickness was more decreased in the aflibercept in-jection group. Especially, there was a statistically significant difference between the two groups at 1, 2 and 3 months after injection. * Compared by Student’s t-test, p < 0.05.

• 

  Figure 4. Mean change in subfoveal choroidal thickness (SFCT) in typical wet age-related macular degeneration and polypoidal cho-roidal vasculopathy. (A) Mean change in SFCT in typical wet age-related macular degeneration. There was no significant difference between aflibercept and ranibizumab group ( p > 0.05). (B) Mean change SFCT in polypoidal choroidal vasculopathy. SFCT was more decreased in the aflibercept injection group at 1, 2 and 3 months after initial injection ( p < 0.05). * Compared by Student’s t-test, p < 0.05.

• 

  Figure 5. Changes in best corrected visual acuity (BCVA), central macular thickness (CMT) and subfoveal choroidal thickness (SFCT) between only 3 monthly loading group and additional treatment after 3 loading dose group. (A) BCVA was not significantly different between the two groups after aflibercept injection. (B) BCVA was not significantly different between the two groups after ranibizumab injection. (C) CMT was not significantly different between the two groups after aflibercept injection. (D) CMT was not significantly different between the two groups after ranibizumab injection. (E) SFCT was not significantly different between the two groups after aflibercept injection. (F) SFCT was not significantly different between the two groups after ranibizumab injection. Compared by Student’s t-test. ETDRS = Early Treatment Diabetic Retinopathy Study.

Reference

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