J Korean Soc Radiol.  2017 Mar;76(3):211-215. 10.3348/jksr.2017.76.3.211.

Squamous Cell Carcinomas of the Lung Which Presented as Numerous Polypoid Nodules in the Tracheobronchial Tree: A Case Report

• Lee HG
• Choi YW
• Yoon HJ
• Paik SS

• KMID: 2371688
• DOI: http://doi.org/10.3348/jksr.2017.76.3.211

Abstract

We report a case of squamous cell carcinomas of the lung, which presented as numerous polypoid nodules in the tracheobronchial tree. They occurred at two years and 7 months after resection of squamous cell carcinoma, which presented as a lung nodule in the left lower lobe, and at 7 months after resection of tracheal squamous cell carcinoma.

MeSH Terms

Carcinoma, Squamous Cell*
Epithelial Cells*
Lung Neoplasms
Lung*
Neoplasms, Second Primary
Trees*

Figure

• 

  Fig. 1. A case of squamous cell carcinomas of the lung, which presented as multiple tracheobronchial polyps in a 61-year-old male. A. Initial CT without enhancement axial image mediastinal window shows a 2 cm-sized nodule in the left lower lobe, which was confirmed to be moderately differentiated squamous cell carcinoma by histopathologic examination through wedge resection (arrow). B, C. Follow-up CT without enhancement axial and coronal image mediastinal windows obtained two years after wedge resection show a 1.5-cm-sized mural nodule along the left side of the trachea with adjacent focal tracheal wall thickening. After tracheal resection, moderately differentiated squamous cell carcinoma was detected by histopathologic examination (arrow). D, E. CT was obtained seven months after resection of the tracheal lesion, and the coronal lung window images show innumerable polypoid nodules along the trachea, both main bronchi, and the right bronchus intermedius. Squamous cell carcinoma in situ was diagnosed by histopathologic examination through bronchoscopic biopsy.

Reference

1. Obusez EC, Jamjoom L, Kirsch J, Gildea T, Mohammed TL. Computed tomography correlation of airway disease with bronchoscopy: part I–nonneoplastic large airway diseases. Curr Probl Diagn Radiol. 2014; 43:268–277.

2. Ling IT, Mulrennan SA, Phillips MJ. Multiple endobronchial polyps. J Bronchology Interv Pulmonol. 2011; 18:154–157.

3. Yoon RG, Kim MY, Song JW, Chae EJ, Choi CM, Jang S. Primary endobronchial marginal zone B-cell lymphoma of bronchus-associated lymphoid tissue: CT findings in 7 patients. Korean J Radiol. 2013; 14:366–374.

4. Burke G, McCaughan B, Glanville A. Metachronous tracheal squamous cell carcinoma treated with Nd: YAG laser. Respirol Case Rep. 2015; 3:22–24.

5. Youn HC, Kim YH, Lee YK, Kim GY. Multiple endotracheal and endobronchial metastases after pneumonectomy for a primary lung cancer: a case report. Thorac Cancer. 2013; 4:453–456.

6. Okita R, Shimizu K, Mimura T, Miyata Y, Okada M, Arihiro K. Suggestive synchronous triple squamous cell carcinoma of the lung in the same lobe. Gen Thorac Cardiovasc Surg. 2010; 58:427–430.

7. Martini N, Melamed MR. Multiple primary lung cancers. J Thorac Cardiovasc Surg. 1975; 70:606–612.

8. Girard N, Deshpande C, Lau C, Finley D, Rusch V, Pao W, et al. Comprehensive histologic assessment helps to differen-tiate multiple lung primary nonsmall cell carcinomas from metastases. Am J Surg Pathol. 2009; 33:1752–1764.

9. van Rens MT, Eijken EJ, Elbers JR, Lammers JW, Tilanus MG, Slootweg PJ. p53 mutation analysis for definite diagnosis of multiple primary lung carcinoma. Cancer. 2002; 94:188–196.

10. Hwang HJ, Kim MY, Kim SS, Choi CM. CT Characteristic of early local recurrence after resection of the squamous cell carcinoma: comparison with CT characteristics of stump deformity or granulation tissue at stump site. Medicine (Bal-timore). 2015; 94:e1691.