J Korean Ophthalmol Soc.  2017 Feb;58(2):222-225. 10.3341/jkos.2017.58.2.222.

Solitary Neurofibroma Occurred on the Eyelid Margin without Neurofibromatosis: A Case Report

  • 1Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea. kcyoon@jnu.ac.kr
  • 2Department of Pathology, Chonnam National University Medical School, Gwangju, Korea.


We report a rare case of solitary neurofibroma on the eyelid margin without neurofibromatosis.
A 46-year-old male presented with a well-define small nodular lesion on the right upper eyelid margin that had not changed for 10 years. Surgical excision and biopsy were performed. Histological examination showed spindle-shaped cells in the fibrous stroma on hematoxylin & eosin staining, and immunohistochemical staining revealed S-100 protein-positive cells. Dermatologic, neurologic, and genetic evaluations showed no evidence of systemic neurofibromatosis. Six months after operation, there was no evidence of local recurrence.
To the best of our knowledge, this is the first case of solitary neurofibroma involving the eyelid margin without neurofibromatosis in Korea. Neurofibroma should be considered in a differential diagnosis of eyelid mass and can be successfully managed with surgical excision.


Eyelid mass; Neurofibroma; Neurofibromatosis

MeSH Terms

Diagnosis, Differential
Eosine Yellowish-(YS)
Middle Aged
Eosine Yellowish-(YS)


  • Figure 1. Clinical photographs of a 46-year-old man. There was well-defined nodular lesion in the right upper eyelie margin (A, B).

  • Figure 2. Histologic examination of the patient. (A) Hematoxylin and eosin stained section (×200) shows spindle shaped cells in the fibrous stroma. (B) Immunohistochemical staining (×200) reveales S-100 protein positive cells.

  • Figure 3. Photographs of 6 months after operation. There was no evidence of local recurrence at the operation site (A, B).



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