J Korean Soc Clin Toxicol.  2016 Dec;14(2):71-77. 10.22537/jksct.2016.14.2.71.

Clinical Characteristics of Patients after Aryloxyphenoxy Propionate Herbicide Ingestion

• Lim J
• Moon J
• Chun B

• KMID: 2368180
• DOI: http://doi.org/10.22537/jksct.2016.14.2.71

Abstract

PURPOSE
No studies have been conducted to investigate the acute toxicity of aryloxyphenoxypropionate herbicides in humans following ingestion. Therefore, this study was conducted to investigate the clinical characteristics of aryloxyphenoxypropionate herbicide poisoning and provide guidance for physicians treating patients who have ingested these types of herbicides.
METHODS
A retrospective observational case series was conducted using ten patients with history of aryloxyphenoxy propionate herbicide. Data were collected for clinical manifestation, management and final outcome.
RESULTS
The most common symptoms were gastrointestinal irritation and an altered mental state (Glasgow Coma Scale<15). An elevated lactate level was a common laboratory abnormality, and prolonged QTc interval was commonly observed. These clinical features normalized within one day of supportive treatment.
CONCLUSION
The acute toxicity of aryloxyphenoxypropionate herbicides in humans is manageable with supportive treatment. However, physicians should take into account depressed consciousness, the possibility of arrhythmia, and an elevated lactate level when planning their treatment strategy.

Keyword

Aryloxyphenoxy propionate herbicide; Poisoning; Acetyl-CoA carboxylase

MeSH Terms

Acetyl-CoA Carboxylase
Arrhythmias, Cardiac
Coma
Consciousness
Diethylpropion*
Eating*
Herbicides
Humans
Lactic Acid
Poisoning
Retrospective Studies
Acetyl-CoA Carboxylase
Diethylpropion
Herbicides
Lactic Acid