J Korean Ophthalmol Soc.  2017 Jan;58(1):93-97. 10.3341/jkos.2017.58.1.93.

A Case of Retinal Hemorrhage Following a Dexamethasone Intravitreal Implant

• Kim MH
• Lee YH

• KMID: 2367849
• DOI: http://doi.org/10.3341/jkos.2017.58.1.93

Abstract

PURPOSE
To report a case of retinal hemorrhage after a dexamethasone (Ozurdex®, Allergan, Irvine, CA, USA) intravitreal implant injection in macular edema (ME) secondary to central retinal vein occlusion (CRVO).
CASE SUMMARY
A 60-year-old woman visited our hospital for ME secondary to CRVO in the right eye. Intravitreal bevacizumab injection and vitrectomy was conducted three times, but ME did not improve. Then, dexamethasone intravitreal implant was injected without any problems. Right after the dexamethasone intravitreal implant injection, retinal hemorrhage (2 disc diopter size) was observed in the infero-temporal area on fundus examination. Retinal hemorrhage completely disappeared 1 month after injection without other treatment.
CONCLUSIONS
A case of dexamethasone intravitreal implant associated with retinal hemorrhage has not been previously reported in Korea. Althrough retinal hemorrhage was observed, it resolved spontaneously without treatment.

Keyword

Dexamethasone intravitreal implant; Ozurdex®; Retinal hemorrhage

MeSH Terms

Bevacizumab
Dexamethasone*
Female
Humans
Korea
Macular Edema
Middle Aged
Retinal Hemorrhage*
Retinal Vein
Retinaldehyde*
Vitrectomy
Bevacizumab
Dexamethasone
Retinaldehyde

Figure

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  Figure 1. Patient’s fundus photograph, optical coherence to-mography and fluorescein angiography at initial presentation. Fundus photograph (A) revealed retinal hemorrhage. Optical co-herence tomography (B) show severe macular edema. Fluorescein angiography (C) show central retinal vein occlusion.

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  Figure 2. Patient’s fundus photograph and optical coherence tomography after intravitreal bevacizumab injection twice and vitrectomy. Fundus photograph (A), optical coherence tomography (B) show the macular edema did not improved.

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  Figure 3. Patient’s fundus before and after dexamethasone intravitreal implant injection. (A) Before the injection show no retinal hemorrhage on inferotemporal fundus area. (B) Right after the injection show retinal hemorrhage (arrowheads) on inferotemporal fundus area. (C) Three days after injection shows the retinal hemorrhage (arrows) almost disappeared. (D) One month after injection show the retinal hemorrhage complete disappeared.

Reference

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