Korean J Ophthalmol.  2014 Apr;28(2):192-193. 10.3341/kjo.2014.28.2.192.

Reversal of Early Central Retinal Vein Occlusion by Alleviating Optic Nerve Edema with an Intravitreal Dexamethasone Implant

• Cho YJ
• Lee DH
• Kang HM
• Kim M
• Koh HJ

• KMID: 1792117
• DOI: http://doi.org/10.3341/kjo.2014.28.2.192

Abstract

This case describes the reversal of early central retinal vein occlusion (CRVO) with disc swelling after intravitreal dexamethasone implant (Ozurdex) injection. A 44-year-old female presented with sudden-onset intermittent blurred vision in her left eye. Fundus examination revealed multiple retinal hemorrhages without macular edema (ME). Two weeks later, an increased number of retinal hemorrhages with severe disc swelling were noted with still no sign of ME. An intravitreal dexamethasone implant was injected. Five days later, there were improvements in disc swelling and retinal hemorrhage. One month later, her subjective visual symptoms were completely improved, and fundus examination revealed marked improvement along with almost complete resolution of disc swelling. Intravitreal dexamethasone implant injection may potentially change the natural course of CRVO progression and its various subsequent complications.

Keyword

Central retinal vein occlusion; Intravitreal dexamethasone implant; Optic nerve edema

MeSH Terms

Adult
Dexamethasone/*administration & dosage
Drug Implants
Female
Glucocorticoids/*administration & dosage
Humans
Intravitreal Injections
Papilledema/*drug therapy
Retinal Vein/*drug effects
Retinal Vein Occlusion/*drug therapy
Treatment Outcome
Dexamethasone
Drug Implants
Glucocorticoids

Figure

• 

  Fig. 1 (A) At first visit, fundus photography (FP) showed multiple retinal, preretinal, and subretinal hemorrhages with tortuous retinal vasculature and (B) f luorescein angiography revealed faint leakage during the late phase with no sign of non-perfusion. (C) Two weeks later, FP showed an increased number of retinal hemorrhages with severe disc swelling and (D) optical coherence tomography revealed no sign of macular edema. (E) Five days after the treatment, FP showed improved disc swelling and hemorrhages. (F) One month after the treatment, FP showed marked improvement of retinal hemorrhages and vascular tortuosity along with almost complete resolution of disc swelling.

Reference

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