J Korean Ophthalmol Soc.  2016 Apr;57(4):667-671. 10.3341/jkos.2016.57.4.667.

A Case of Anterior Migration of Fragmented Dexamethasone Intravitreal Implant

Affiliations
  • 1Department of Ophthalmology, Gyeongsang National University School of Medicine, Jinju, Korea. in0chung@hanmail.net
  • 2Gyeongsang Institute of Health Science, Gyeongsang National University, Jinju, Korea.

Abstract

PURPOSE
To report a case of fragmentation and anterior migration occurred after dexamethasone intravitreal implant (Ozurdex®, Allergan, Irvine, CA, USA) injection in a branch retinal vein occlusion patient.
CASE SUMMARY
A 66-year-old male was referred for blurred vision. He received cataract surgery in 1986 and was diagnosed with central retinal vein obstruction in 2011 in the right eye. For treatment of macular edema, dexamethasone intravitreal implant was performed in the right eye. One week after implantation, a fragment of the dexamethasone implant migrated to the anterior chamber with corneal edema and surgical removal was performed immediately. One day after removal, the remaining fragmented implant migrated to the anterior chamber and corneal edema still existed. The fragmented implant was removed with anterior chamber irrigation. After removal, corneal edema improved and visual acuity was recovered.
CONCLUSIONS
Anterior migrated dexamethasone implant could induce corneal complications, such as corneal edema and corneal decompensation and might lower the corneal endothelial cell even if immediately removed. We report a case of corneal edema, which was induced by anterior migration of a fragmented dexamethasone implant and recovered with immediate surgical removal.

Keyword

Anterior chamber migration; Corneal edema; Dexamethasone intravitreal implant; Fragmentation; Ozurdex®

MeSH Terms

Aged
Anterior Chamber
Cataract
Corneal Edema
Dexamethasone*
Endothelial Cells
Humans
Macular Edema
Male
Retinal Vein
Retinal Vein Occlusion
Visual Acuity
Dexamethasone
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