Child Kidney Dis.  2016 Oct;20(2):88-91. 10.3339/jkspn.2016.20.2.88.

Nonobstructive Bilateral Hydronephrosis & Hydroureter from Nephrogenic Diabetes Insipidus with a Novel Mutation of AQP2 Gene (p.A123G)

• Song KS
• Soo JI
• Namgoong M

• KMID: 2366603
• DOI: http://doi.org/10.3339/jkspn.2016.20.2.88

Abstract

Nephrogenic diabetes insipidus (NDI) can cause nonobstructive hydronephrosis. Congenital NDI (CNDI) is caused by a genetic mutation. This case report presents a 12-year-old girl who was incidentally diagnosed with nonobstructive hydronephrosis due to NDI caused by AQP2 gene mutation after being evaluated for microscopic hematuria found on routine health examination at school. The patient's medical and family history was unremarkable, and she complained of nocturia only at the time of the clinic visit. Bilateral hydronephrosis on abdominal ultrasonography prompted a water deprivation test, leading to diagnosis of NDI. Genetic study confirmed p.Asn (AAC)123Ser (AGC) in exon 2 of the AQP2 gene. Polyuria and hydronephrosis improved following arginine-vasopressin therapy. CNDI responsive to treatment should be considered as a possible cause of nonobstructive hydroureter.

Keyword

Nonobstructive hydronephrosis; Hydroureter; Congenital nephrogenic diabetes insipidus

MeSH Terms

Ambulatory Care
Child
Diabetes Insipidus, Nephrogenic*
Diagnosis
Exons
Female
Hematuria
Humans
Hydronephrosis*
Nocturia
Polyuria
Ultrasonography
Water Deprivation