Genomics Inform.  2016 Dec;14(4):234-240. 10.5808/GI.2016.14.4.234.

Tissue Specific Expression Levels of Apoptosis Involved Genes Have Correlations with Codon and Amino Acid Usage

Affiliations
  • 1Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz 61357-83151, Iran. Mohamad.hajari@gmail.com tahmasebi-ma@ajums.ac.ir
  • 2Department of Molecular Genetics, Faculty of Biosciences, Tarbiat Modares University of Tehran, Tehran 14115116, Iran.
  • 3Department of Medical Genetics, Nika Center of Preventive Medicine and Health Promotion, Tehran 1418944711, Iran.
  • 4Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357-15794, Iran. Mohamad.hajari@gmail.com tahmasebi-ma@ajums.ac.ir

Abstract

Different mechanisms, including transcriptional and post transcriptional processes, regulate tissue specific expression of genes. In this study, we report differences in gene/protein compositional features between apoptosis involved genes selectively expressed in human tissues. We found some correlations between codon/amino acid usage and tissue specific expression level of genes. The findings can be significant for understanding the translational selection on these features. The selection may play an important role in the differentiation of human tissues and can be considered for future studies in diagnosis of some diseases such as cancer.

Keyword

apoptosis; codon; gene expression regulation; translation
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