Clin Exp Reprod Med.  2016 Dec;43(4):207-214. 10.5653/cerm.2016.43.4.207.

Anti-Müllerian hormone as a predictor of polycystic ovary syndrome treated with clomiphene citrate

• Hestiantoro A
• Negoro YS
• Afrita Y
• Wiweko B
• Sumapradja K
• Natadisastra M

• KMID: 2364657
• DOI: http://doi.org/10.5653/cerm.2016.43.4.207

Abstract

OBJECTIVE
This study aimed to determine the threshold of anti-Müllerian hormone (AMH) as predictor of follicular growth failure in polycystic ovary syndrome (PCOS) patients treated with clomiphene citrate (CC).
METHODS
Fifty female subjects with PCOS were recruited and divided into two groups based on successful and unsuccessful follicular growth. Related variables such as age, infertility duration, cigarette smoking, use of Moslem hijab, sunlight exposure, fiber intake, body mass index, waist circumference, AMH level, 25-hydroxy vitamin D level, and growth of dominant follicles were obtained, assessed, and statistically analyzed.
RESULTS
The AMH levels of patients with successful follicular growth were significantly lower (p=0.001) than those with unsuccessful follicular growth (6.10±3.52 vs. 10.43±4.78 ng/mL). A higher volume of fiber intake was also observed in the successful follicular growth group compared to unsuccessful follicular growth group (p=0.001). Our study found the probability of successful follicle growth was a function of AMH level and the amount of fiber intake, expressed as Y=-2.35+(-0.312×AMH level)+(0.464×fiber intake) (area under the curve, 0.88; 95% confidence interval, 0.79-0.98; p<0.001).
CONCLUSION
The optimal threshold of AMH level in predicting the failure of follicle growth in patients with PCOS treated with CC was 8.58 ng/mL.

Keyword

Anti-Müllerian hormone; Clomiphene citrate; Ovarian follicle; Polycystic ovary syndrome

MeSH Terms

Body Mass Index
Clomiphene*
Female
Humans
Infertility
Ovarian Follicle
Polycystic Ovary Syndrome*
Smoking
Sunlight
Vitamin D
Waist Circumference
Clomiphene
Vitamin D