Gut Liver.  2016 Mar;10(2):237-243. 10.5009/gnl14439.

Does Polyethylene Glycol (PEG) Plus Ascorbic Acid Induce More Mucosal Injuries than Split-Dose 4-L PEG during Bowel Preparation?

• Kim MS
• Park J
• Park JH
• Kim HJ
• Jang HJ
• Joo HR
• Kim JY
• Choi JH
• Heo NY
• Park SH
• Kim TO
• Yang SY

• KMID: 2363968
• DOI: http://doi.org/10.5009/gnl14439

Abstract

BACKGROUND/AIMS
The aims of this study were to compare the bowel-cleansing efficacy, patient affinity for the preparation solution, and mucosal injury between a split dose of poly-ethylene glycol (SD-PEG) and low-volume PEG plus ascorbic acid (LV-PEG+Asc) in outpatient scheduled colonoscopies.
METHODS
Of the 319 patients, 160 were enrolled for SD-PEG, and 159 for LV-PEG+Asc. The bowel-cleansing efficacy was rated according to the Ottawa bowel preparation scale. Patient affinity for the preparation solution was assessed using a questionnaire. All mucosal injuries observed during colonoscopy were biopsied and histopathologically reviewed.
RESULTS
There was no significant difference in bowel cleansing between the groups. The LV-PEG+Asc group reported better patient acceptance and preference. There were no significant differences in the incidence or characteristics of the mucosal injuries between the two groups.
CONCLUSIONS
Compared with SD-PEG, LV-PEG+Asc exhibited equivalent bowel-cleansing efficacy and resulted in improved patient acceptance and preference. There was no significant difference in mucosal injury between SD-PEG and LV-PEG+Asc. Thus, the LV-PEG+Asc preparation could be used more effectively and easily for routine colonoscopies without risking significant mucosal injury.

Keyword

Colonoscopy; Bowel preparation; Polyethylene glycols; Ascorbic acid; Mucosal injury

MeSH Terms

Adult
Ascorbic Acid/administration & dosage/*adverse effects
Cathartics/administration & dosage/*adverse effects
Colonoscopy/methods
Drug Therapy, Combination
Female
Humans
Intestinal Mucosa/drug effects/*injuries
Male
Middle Aged
Patient Compliance
Patient Satisfaction
Polyethylene Glycols/administration & dosage/*adverse effects
Preoperative Care/*adverse effects/methods
Surveys and Questionnaires
Vitamins/administration & dosage/adverse effects
Ascorbic Acid
Cathartics
Vitamins
Polyethylene Glycols