Gut Liver.  2016 Mar;10(2):212-219. 10.5009/gnl14416.

Comparison between Resectable Helicobacter pylori-Negative and -Positive Gastric Cancers

• Kim HJ
• Kim N
• Yoon H
• Choi YJ
• Lee JY
• Kwon YH
• Yoon K
• Jo HJ
• Shin CM
• Park YS
• Park DJ
• Kim HH
• Lee HS
• Lee DH

• KMID: 2363965
• DOI: http://doi.org/10.5009/gnl14416

Abstract

BACKGROUND/AIMS
Controversy exists regarding the characteristics of Helicobacter pylori infection-negative gastric cancer (HPIN-GC). The aim of this study was to evaluate clinicopathologic features of HPIN-GC compared to H. pylori infection-positive gastric cancer (HPIP-GC) using a comprehensive analysis that included genetic and environmental factors.
METHODS
H. pylori infection status of 705 resectable gastric cancer patients was determined by the rapid urease test, testing for anti-H. pylori antibodies, histologic analysis and culture of gastric cancer tissue samples, and history of H. pylori eradication. HPIN-GC was defined as gastric cancer that was negative for H. pylori infection based on all five methods and that had no evidence of atrophy in histology or serology.
RESULTS
The prevalence of HPIN-GC was 4% (28/705). No significant differences with respect to age, sex, smoking, drinking, family history of gastric cancer or obesity were observed between the two groups. HPIN-GC tumors were marginally more likely to involve the cardia (14.3% for HPIN-GC vs 5.3% for HPIP-GC, p=0.068). The Lauren classification, histology, and TNM stage did not differ according to H. pylori infection status. Microsatellite instability was not different between the two groups, but p53 overexpression in HPIN-GC was marginally higher than in HPIP-GC (56.0% for HPIN-GC vs 37.0% for HPIP-GC, p=0.055).
CONCLUSIONS
The prevalence of HPIN-GC was extremely low, and its clinicopathologic characteristics were similar to HPIP-GC.

Keyword

Helicobacter pylori; Stomach neoplasms; Negative infection; Atrophy

MeSH Terms

Antibodies, Bacterial/analysis
Female
Helicobacter Infections/*complications/epidemiology/microbiology
*Helicobacter pylori
Humans
Male
Middle Aged
Prevalence
Prospective Studies
Republic of Korea/epidemiology
Stomach Neoplasms/epidemiology/*microbiology/*pathology/surgery
Urease/analysis
Antibodies, Bacterial
Urease