Ann Dermatol.  1990 Jan;2(1):35-38. 10.5021/ad.1990.2.1.35.

A Pemphigus Vulgaris with IgG1 and IgG4 Subclass Autoantibodies

• Lee SW
• Rhe JK
• Houh D
• Oh YJ
• Kim YW
• Houh W

• KMID: 2362055
• DOI: http://doi.org/10.5021/ad.1990.2.1.35

Abstract

The distribution of pemphigus subclass autoantibodies in a patient with pemphigus vulgaris (PV) has been investigated by semiquantitative indirect immunofluorescence (IIF), using the HP series monoclonal antibodies specific for four human IgG subclasses on human foreskins. IgG1 and IgG4 intercellular substance-specific autoantibodies were detected in the serum of the patient, whereas IgG2 and IgG3 autoantibodies were absent. In addition to foreskins, human tonsillar epithelia were used as substrates of IIF for detecting the PV autoantibodies and it was one of satisfactory substitutes for monkey esophagus.

Keyword

Human tonsillar epithelium; Monoclonal antibodies specific for human IgG subclasses; Pemphigus subclass autoantibodies

MeSH Terms

Antibodies, Monoclonal
Autoantibodies*
Esophagus
Fluorescent Antibody Technique, Indirect
Foreskin
Haplorhini
Humans
Immunoglobulin G*
Pemphigus*
Antibodies, Monoclonal
Autoantibodies
Immunoglobulin G