Ann Dermatol.  1992 Jul;4(2):91-94. 10.5021/ad.1992.4.2.91.

Two Cases of Cutaneous Leishmaniasis Treated with Itraconazole

• Park BC
• Chae HJ
• Yi JY
• Cho BK
• Houh W
• Kim DJ
• Choi WY

• KMID: 2361747
• DOI: http://doi.org/10.5021/ad.1992.4.2.91

Abstract

Two patients with cutaneous leishmaniasis were treated with itraconazole. One patient was a 24-year-old man who had several erythematous papulonodules on the extremities for 1 month, which revealed cutaneous leishmaniasis, histopathologically. He was treated with itraconazole (200 mg/day) for 2 months. After treatment he showed clinical healing and the biopsy specimens no longer showed leishmania organisms. The other patient was a 27-year-old female who had several erythematous papulonodules on the face and neck for 3 months. The skin lesions revealed leishmania organisms in the tissue sections and culture media. She was also treated with itraconazole (200 mg/day) for 2 months. After treatment she also showed satisfying clinical healing and the biopsy specimens revealed no leishmania organisms. No specific side effects were encountered in both patients during the treatment. From these results, itraconazole is considered to be one of the promising anti-leishmanial drugs.

Keyword

Cutaneous leishmaniasis; Itraconazole

MeSH Terms

Adult
Biopsy
Culture Media
Extremities
Female
Humans
Itraconazole*
Leishmania
Leishmaniasis, Cutaneous*
Neck
Skin
Young Adult
Culture Media
Itraconazole