Ann Dermatol.  1993 Jul;5(2):125-129. 10.5021/ad.1993.5.2.125.

Graft-Versus-Host Disease Limited to the Irradiated Skin

• Park YM
• Choi SB
• Yi JY
• Cho BK
• Houh W
• Kim CC

• KMID: 2361706
• DOI: http://doi.org/10.5021/ad.1993.5.2.125

Abstract

We present two very interesting cases of acute graft-versus-host disease (GVHD), whose skin rashes initially appeared on the localized area of total nodal irradiation (TNI) performed previously to prevent graft rejection and/or GVHD. The histopathologic findings showed some dyskeratotic cells in the epidermis and perivascular mononuclear cell infiltration in the upper dermis. The immunohistochemical studies revealed that HLA-DR was diffusely strongly positive in a number of keratinocytes, whereas both CD4 and CD8 were focally weakly positive in the perivascular lymphocytes in the upper dermis. Later on, liver dysfunction and diarrhea developed and skin rashes began to spread over the other parts of the body in those two patients.

Keyword

Graft-verus-host disease; Irradiation

MeSH Terms

Dermis
Diarrhea
Epidermis
Exanthema
Graft Rejection
Graft vs Host Disease*
HLA-DR Antigens
Humans
Keratinocytes
Liver Diseases
Lymphocytes
Skin*
HLA-DR Antigens