Korean J Biol Psychiatry.
2016 Nov;23(4):140-147. 10.0000/kjbp.2016.23.4.140.
Association between the Alu Insertion/Deletion Polymorphism in the Tissue-Type Plasminogen Activator Gene and Mirtazapine Response in Koreans with Major Depression
- Affiliations
-
- 1Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea. leeminso@korea.ac.kr
- 2Department of Medical Bioscience, Soonchunhyang University, Bucheon, Korea.
- KMID: 2361589
- DOI: http://doi.org/10.0000/kjbp.2016.23.4.140
Abstract
OBJECTIVES
To determine the relationship between the Alu insertion/deletion (I/D) polymorphism in the tissue-type plasminogen activator (tPA) gene and the clinical outcome of mirtazapine treatment in Korean major depressive disorder (MDD) patients.
METHODS
We enrolled 422 patients in this study. Symptoms were evaluated using the 21-item Hamilton Depression Rating (HAMD-21) Scale. After 1, 2, 4, and 8 weeks of mirtazapine treatment, the association between the Alu I/D polymorphism in the tPA gene and remission/response outcomes were evaluated.
RESULTS
The proportion of I/I homozygotes in responders was higher than that in non-responders, whereas the proportion of D/D homozygotes in responders was lower than that in non-responders at 8 weeks of treatment (p = 0.032, OR = 1.57). The percentage decline of HAMD-21 scores in I allele carriers was larger than that of D/D homozygotes at 2 and 8 weeks of treatment (p = 0.035 and 0.007, respectively). I allele carriers were associated with remission at 8 weeks of treatment (p = 0.047, OR = 2.2).
CONCLUSIONS
These results show that treatment response and remission to mirtazapine were associated with the Alu I/D polymorphism of the tPA gene. This suggests the Alu I/D polymorphism may be a potential genetic marker for the prediction of therapeutic response to mirtazapine treatment in patients with MDD.
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