Korean J Urol Oncol.
2016 Aug;14(2):82-87. 10.22465/kjuo.2016.14.2.82.
Thrombotic Thrombocytopenic Purpura Associated with Bone Marrow Necrosis Complicating Metastatic Extra-Mammary Paget's Disease
- Affiliations
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- 1Yonsei University Wonju College of Medicine, Wonju, Korea.
- 2Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. jaelyun@amc.seoul.kr
- 3Department of Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- 4Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- 5Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- 6Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- KMID: 2361568
- DOI: http://doi.org/10.22465/kjuo.2016.14.2.82
Abstract
- As extra-mammary Paget's disease is rare and usually diagnosed at early stage when it is highly curable with surgical resection, it is much rarer to see patients with recurrent metastatic disease. Thrombotic thrombocytopenic purpura in patients with metastatic solid cancer is also a rare disease and may result from bone marrow metastasis or bone marrow necrosis. For the latter, the majority of cases are not eligible for systemic chemotherapy for rapid disease progression and poor performance status. Herein, authors report a patient with thrombotic thrombocytopenic purpura associated with bone marrow necrosis complicating extra-mammary Paget's disease who was successfully treated with docetaxel and carboplatin combination chemotherapy.
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