Exp Mol Med.  2016 Mar;48(3):e219. 10.1038/emm.2016.6.

Pancreatic regulation of glucose homeostasis

• Röder PV
• Wu B
• Liu Y
• Han W

• KMID: 2361506
• DOI: http://doi.org/10.1038/emm.2016.6

Abstract

In order to ensure normal body function, the human body is dependent on a tight control of its blood glucose levels. This is accomplished by a highly sophisticated network of various hormones and neuropeptides released mainly from the brain, pancreas, liver, intestine as well as adipose and muscle tissue. Within this network, the pancreas represents a key player by secreting the blood sugar-lowering hormone insulin and its opponent glucagon. However, disturbances in the interplay of the hormones and peptides involved may lead to metabolic disorders such as type 2 diabetes mellitus (T2DM) whose prevalence, comorbidities and medical costs take on a dramatic scale. Therefore, it is of utmost importance to uncover and understand the mechanisms underlying the various interactions to improve existing anti-diabetic therapies and drugs on the one hand and to develop new therapeutic approaches on the other. This review summarizes the interplay of the pancreas with various other organs and tissues that maintain glucose homeostasis. Furthermore, anti-diabetic drugs and their impact on signaling pathways underlying the network will be discussed.

MeSH Terms

Blood Glucose
Brain
Comorbidity
Diabetes Mellitus, Type 2
Glucagon
Glucose*
Hand
Homeostasis*
Human Body
Insulin
Intestines
Liver
Neuropeptides
Pancreas
Peptides
Prevalence
Blood Glucose
Glucagon
Glucose
Insulin
Neuropeptides
Peptides