Ann Dermatol.  1994 Jul;6(2):249-255. 10.5021/ad.1994.6.2.249.

Primary Cutaneous B Cell Lymphoma

• Kim KH
• Nam JT
• Joh GY
• Lee YH
• Hong SH
• Kim CW
• Kim KW

• KMID: 2361472
• DOI: http://doi.org/10.5021/ad.1994.6.2.249

Abstract

We report a case of B-cell lymphoma primarily involving the skin in a 12-year-old boy. The histopathologic findings were compatible with those of small lymphocytic type of non-Hodgkin's lymphoma. A cutaneous lesion was the sole manifestation of his disease without any other organ involvement. Immunophenotypic studies and immunoglobulin gene rearrangement with Southern blot analysis determined its lineages and monoclonality with result of B-cell lineage neoplasm, i. d. CD20⁺, C1323⁺, CD35⁻ and rearranged band on JH probe. We treated him with surgical excision and CVP regimen of chemotherapy (cyclophosphamide, vincristine, prednisolone). There is no recurrence or metastasis during the last six months.

Keyword

Immunophenotyping; Immunoglobulin gene rearrangement Primary cutaneous B-cell lymphoma(small lymphocytic type)

MeSH Terms

B-Lymphocytes
Blotting, Southern
Child
Drug Therapy
Genes, Immunoglobulin
Humans
Immunophenotyping
Lymphoma, B-Cell*
Lymphoma, Non-Hodgkin
Male
Neoplasm Metastasis
Recurrence
Skin
Vincristine
Vincristine