Ann Dermatol.  1995 Oct;7(4):308-312. 10.5021/ad.1995.7.4.308.

The Effect of Calcitonin Gene-Related Peptide on Hair Growth in Vitro

• Suh DH
• Eun HC

• KMID: 2361359
• DOI: http://doi.org/10.5021/ad.1995.7.4.308

Abstract

BACKGROUND
Calcitonin gene-related peptide(CGRP)-containing nerve fibers are widely distributed in the skin including the area around hair follicles.
OBJECTIVE
This study was undertaken to investigate the effect of CGRP on normal hair growth in vitro.
METHODS
CGRP was added to isolated anagen hair follicles in Williams' E media or keratinocyte growth media(KGM). Measuring the length of hair follicles and thymidine uptake were used for hair growth parameters.
RESULTS
CGRP-treated groups generally showed no significant difference of hair follicle length and thymidine uptake in both media compared to the controls. However, hair follicle length was significantly increased at a high concentration of CGRP in KGM compared to the controls.
CONCLUSION
Our study suggested that CGRP may be a promoter of hair follicle growth in vitro.

Keyword

Calcitonin gene-related peptide(CGRP); Growth; Hair follicle

MeSH Terms

Calcitonin Gene-Related Peptide*
Calcitonin*
Hair Follicle
Hair*
In Vitro Techniques*
Keratinocytes
Nerve Fibers
Skin
Thymidine
Calcitonin
Calcitonin Gene-Related Peptide
Thymidine