Clin Exp Otorhinolaryngol.  2016 Dec;9(4):339-345. 10.21053/ceo.2015.01641.

The Lung Function Impairment in Non-Atopic Patients With Chronic Rhinosinusitis and Its Correlation Analysis

• Zhang L
• Zhang L
• Zhang CH
• Fang XB
• Huang ZX
• Shi QY
• Wu LP
• Wu P
• Wang ZZ
• Liao ZS

• KMID: 2360765
• DOI: http://doi.org/10.21053/ceo.2015.01641

Abstract

OBJECTIVES
Chronic rhinosinusitis (CRS) is common disease in otorhinolaryngology and will lead to lower airway abnormality. However, the only lung function in CRS patients and associated factors have not been much studied.
METHODS
One hundred patients with CRS with nasal polyps (CRSwNP group), 40 patients with CRS without nasal polyps (CRSsNP group), and 100 patients without CRS were enrolled. The difference in lung function was compared. Meanwhile, CRSwNP and CRSsNP group were required to undergo a bronchial provocation or dilation test. Additionally, subjective and objective outcomes were measured by the visual analogue scale (VAS), 20-item Sino-Nasal Outcome Test (SNOT-20), Lund-Mackay score, Lund-Kennedy endoscopic score. The correlation and regression methods were used to analyze the relationship between their lung function and the above parameters.
RESULTS
The forced expiratory volume in 1 second (FEV1) and forced expiratory flow between 25% and 75% of forced vital capacity (FEF25-75) of CRSwNP group were significantly lower than other groups (P<0.05). On peak expiratory flow, there was no difference between three groups. In CRSwNP group, FEV1 was negatively correlated with peripheral blood eosinophil count (PBEC) and duration of disease (r=-0.348, P=0.013 and r=-0.344, P=0.014, respectively), FEF25-75 negatively with VAS, SNOT-20 (r=-0.490, P=0.028 and r=-0.478, P=0.033, respectively) in CRSsNP group. The incidence of positive bronchial provocation and dilation test was lower in CRSwNP group (10% and 0%, respectively), with both 0% in CRSsNP group. The multiple linear regression analysis indicated that change ratio of FEV1 before and after bronchial provocation or dilation test were correlated with PBEC in CRSwNP group (β=0.403, P=0.006).
CONCLUSION
CRS leading to impaired maximum ventilation and small airway is associated with the existence of nasal polyp. Lung function impairments can be reflected by PBEC, duration, VAS, and SNOT-20. In CRSwNP patients, PBEC is independent predictor of FEV₁ change ratio.

Keyword

Chronic Rhinosinusitis; Lung Function; Bronchial Hyperreactivity; Bronchial Provocation Tests

MeSH Terms

Bronchial Hyperreactivity
Bronchial Provocation Tests
Eosinophils
Forced Expiratory Volume
Humans
Incidence
Linear Models
Lung*
Nasal Polyps
Otolaryngology
Ventilation
Vital Capacity

Figure

• 

  Fig. 1. Forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), forced expiratory flow between 25% and 75% of forced vital capacity (FEF25-75) in CRSwNP, CRSsNP and control group. (A, C) FEV1 and FEF25-75 were significantly lower. (B) PEF was no significantly different among three groups. CRSwNP, chronic rhinosinusitis with nasal polyps; CRSsNP, chronic rhinosinusitis without nasal polyps; NS, no significance.

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