Psychiatry Investig.  2016 Nov;13(6):652-658. 10.4306/pi.2016.13.6.652.

The Severity of Sleep Disordered Breathing Induces Different Decrease in the Oxygen Saturation During Rapid Eye Movement and Non-Rapid Eye Movement Sleep

• Choi E
• Park DH
• Yu JH
• Ryu SH
• Ha JH

• KMID: 2360383
• DOI: http://doi.org/10.4306/pi.2016.13.6.652

Abstract

OBJECTIVE
To investigate how differences in oxygen saturation between non-REM (NREM) and REM sleep in patients according to the severity of sleep apnea.
METHODS
We studied 396 male patients diagnosed with simple snoring or obstructive sleep apnea syndrome (OSAS) on nocturnal polysomnography. Patients were divided into groups by the OSAS severity. We compared the average oxygen saturation between REM and NREM sleep in each group.
RESULTS
In the simple snoring group, average oxygen saturation was significantly greater during REM than during NREM sleep. In the severe OSA group alone, average oxygen saturation was greater in NREM than in REM sleep. The difference of NREM-REM average oxygen saturation correlated significantly with AHI in the severe OSA group.
CONCLUSION
More severe hypoxemia was seen in REM than NREM sleep in the severe OSAS group. The differential oxygen decrease between REM and NREM sleep is likely due to the differentially occurring sleep breathing events in each sleep stage according to the SDB severity. The more AHI increases in the severe OSAS patients, the more prominent the hypoxemia of REM sleep compared with NREM sleep is likely to appear. This suggests that the pressure of continuous positive airway pressure should be increased to control the hypoxemia of REM sleep in extremely severe OSAS.

Keyword

Sleep disordered breathing; Obstructive sleep apnea; Oxygen saturation; Non-REM sleep; REM sleep

MeSH Terms

Anoxia
Continuous Positive Airway Pressure
Eye Movements*
Humans
Male
Oxygen*
Polysomnography
Respiration
Sleep Apnea Syndromes*
Sleep Apnea, Obstructive
Sleep Stages
Sleep, REM*
Snoring
Oxygen