J Korean Radiol Soc.  1988 Oct;24(5):678-686. 10.3348/jkrs.1988.24.5.678.

Computed tomographic evaluation of CNS lymphoma

• Park JW
• Suh JH
• Kim DI
• Chung TS

• KMID: 2359197
• DOI: http://doi.org/10.3348/jkrs.1988.24.5.678

Abstract

Malignant lymphoma of the central nervous system(CNS) have exhibition a marked response to radiation therapy, so that early diagnosis may be of value. The authors reviewed 19 patients with diffuse histiocytic lymphoma of thebrain, including 13 with primary disease and 6 with secondary disease. The results fo treatment with radiationthraphy (RT) and/or radiation therapy followed by intrathecal methotaxate (MTx) were analyzed. Both primary and secondary lymphomas exhibited the characteristic CT appearance, a large, solid, homogenously enhanced mass withvarying amount of edema. Multifocal lesions were also seen in primary (7/13) and secondary lymphoma(2/6).Secondary lymphoma affected the leptomeninges and subcortical white matter which was contrasted with the involvement of deep cerebral nuclei and periventircular white matter in primary lymphoma. The recurrence rate was higher in patients treated with RT alone(2/6) than RT and intrathecal MTx(1/11), but necrotizingleukoencephalopathy was developed in 54.5%(6/11) of latter group.

MeSH Terms

Early Diagnosis
Edema
Humans
Lymphoma*
Lymphoma, Large B-Cell, Diffuse
Recurrence
White Matter