Clin Pediatr Hematol Oncol.  2016 Oct;23(2):188-192. 10.15264/cpho.2016.23.2.188.

Three Cases of Pulmonary Hemosiderosis with Long-term Treatment of Deflazacort in Children

Affiliations
  • 1Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea. pedpje@ajou.ac.kr

Abstract

Idiopathic pulmonary hemosiderosis (IPH) is a rare respiratory disease with an unknown etiology, and is diagnosed with laboratory, radiology, and pathology tests. Chief complaints of IPH include hemoptysis, cough, and dyspnea. Since it is considered an immune-mediated disease, the first line of treatment is systemic corticosteroid therapy. The three cases reported here showed a decrease in ferritin level and improvement in the hemoglobin level with prednisolone treatment. However, long-term corticosteroid therapy may cause several side effects, particularly growth retardation and obesity, which can affect growing children. In the present study, all patients had cushingoid symptoms and obesity. Therefore, we switched to deflazacort (DFZ), which has lesser side-effects of weight gain. This report describes clinical courses of the disease and comparison of body mass index of three patients with IPH who took DFZ instead of prednisolone. DFZ was effective for IPH, and is useful for weight gain reduction.

Keyword

Idiopathic pulmonary hemosiderosis; Deflazacort; Body mass index

MeSH Terms

Body Mass Index
Child*
Cough
Dyspnea
Ferritins
Hemoptysis
Hemosiderosis*
Humans
Obesity
Pathology
Prednisolone
Weight Gain
Ferritins
Prednisolone
Full Text Links
  • CPHO
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr