Korean J Anesthesiol.  1976 Dec;9(2):219-222.

Clinical Experiences of Combid Spansule as a Preanesthetie Medicant ( 2,800 Cases Report )

• Song NW
• Cheun JK
• Jung JG

Abstract

Combid is a compound of Compaxine, which is a phenothiazine derivative, and Darbid that is a long acting anticholinergic synthetic. This medicant was originally intended for use in physical and emotional peptic ulcer cases. Because of it's pharmacological action, writers decided to consider the medicant as a preanesthetic medication. From a record of 2800 patients in the hospital for the year 1975 was administered as a premedicant at random, even though some contraindication did occur and is discussed later in this article, the following results were observed. 1. Because of the characteristics of a long acting effect of Combid Spansule, it can be administered orally with sips of water, 2~3 hours prior to operation, eliminating needless preanesthetic shots, without affecting the N.P.O. rule. 2. Sedative and antisialogue effects of the drug have been also satisfactory, therefore it is recommended to use as a premedicant especially in Korea because ether is commonly used. 3. The drug has an additional antiemetic effect to prevent vomiting from ether anesthesia. 4. Some side effects were observed such as dry mouth, tachycardia, fever and extrapyramidal action that occur from overdosage. 5. The contraindications to be considered when using Combid Spansule as a premedicant include dehydration, fever, tachycardia and parkinsonism. 6. Please note the writers do not recommend this application for short procedure such as closed reduction of Colles fracture and simple spinal anesthesia due to the long lasting drying effect.

MeSH Terms

Anesthesia
Anesthesia, Spinal
Antiemetics
Colles' Fracture
Dehydration
Ether
Fever
Humans
Korea
Mouth
Parkinsonian Disorders
Peptic Ulcer
Preanesthetic Medication
Tachycardia
Trimeprazine*
Vomiting
Water
Antiemetics
Ether
Trimeprazine
Water