Korean J Anesthesiol.  1976 Dec;9(2):209-214.

An Experimental Study of Positive End-Expiratong Pressure ( PEEP ) on Blood Gases during General Anesthesia

• Kim KW
• Kim YL
• Kwon MI
• Moon HS

Abstract

Salient features of acute respiratory failure are reduction of functional residual capacity, decreasedlung compliance and increased right to left shunt; and pneumonia, pulmonary congestion, atelectasis pulmonary edema and fibrosis are revealed clinically. PEEP is able to prevent alveolar collapse and avoid atelectatic change and increase functivnal residual capacity and lung compliance with increment of arterial oxygen content. Decreased cardiac output and pulmonary parenchymal damages were noted during high PEEP. Blood gases were observed with IL 213 Blood Gas Analyzer during 5cm H2O of PEEP and general anesthesia in 10 healthy persons. Following results were obtained: 1) 5 cm H2O of PEEP increased PaO2 from 221 torr to 275 torr and PaCO2 from 38. 8 torr to 42. 1 torr. 2) 5 cm H2O of PEEP increased PvO2 from 40 torr to 48 torr and PvCO2 from 44. 1 torr to 49. 3 torr. 3) 5 cm H2O of PEEP increased mean arterial pressure but had no effect on heart rate. 4) 5 cm H2O of PEEP increased C(a-v)DO2 from 5. 306 cc/100ml to 5. 433 cc/100ml. 5) It is noted that 5 cm H2O of PEEP is safe in healthy persons.

MeSH Terms

Anesthesia, General*
Arterial Pressure
Cardiac Output
Compliance
Estrogens, Conjugated (USP)
Fibrosis
Functional Residual Capacity
Gases*
Heart Rate
Humans
Lung Compliance
Oxygen
Pneumonia
Pulmonary Atelectasis
Pulmonary Edema
Respiratory Insufficiency
Estrogens, Conjugated (USP)
Gases
Oxygen