J Cerebrovasc Endovasc Neurosurg.  2016 Sep;18(3):271-275. 10.7461/jcen.2016.18.3.271.

Evaluation and Treatment of the Acute Cerebral Infarction with Convexal Subarachnoid Hemorrhage

Affiliations
  • 1Department of Neurosurgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea. tkddnr79@daum.net

Abstract

Non-traumatic convexal subarachnoid hemorrhage (CSAH) is a comparatively infrequent with various vascular and nonvascular causes, it rarely occurs concomitant to acute ischemic stroke. We report a case of a 59-year-old woman, visited emergency room with right side subjective weakness spontaneously. Magnetic resonance diffusion-weighted images revealed an acute infarction of anterior cerebral arterial territory. Computed tomographic angiography showed a left frontal CSAH without any vascular lesions. And other laboratory studies were non-specific. We treated with dual antiplatelet drugs (cilostazole [Otsuka Pharmaceutical Co., Ltd. tokyo, Japan] and Aspirin [Bayer Pharma AG., Leverkusen, Germany]). She has done well for a follow-up period. (5 months) This case demonstrates the CSAH with acute infarction is rare but need to work up to identify the etiology and antiplatelet dugs are taken into account for treatments.

Keyword

Convexal subarachnoid hemorrhage; Ischemic stroke; Antiplatelet drug; Computed tomographic angiography

MeSH Terms

Angiography
Aspirin
Cerebral Infarction*
Emergency Service, Hospital
Female
Follow-Up Studies
Humans
Infarction
Middle Aged
Platelet Aggregation Inhibitors
Stroke
Subarachnoid Hemorrhage*
Aspirin
Platelet Aggregation Inhibitors

Figure

  • Fig. 1 (A) Computed tomography scan of the patient showing subarachnoid hemorrhage (black arrow) on left frontal convexity. (B) CT angiography shows that both A2 segments were mild focal stenosis (white arrow). (C) Diffusion-weighted images shows a high intensity area in the territory of left anterior cerebral artery. (D) Brain SPECT with Tc-99 m HMPAO shows a small area of decreased perfusion at left frontal area. CT = computed thmography; SPECT = single-photon emission computed tomography; HMPAO = hexamethylpropylene amine oxime; Lt = left; Rt = Right.

  • Fig. 2 (A) Computed tomography shows that low intensity of previous ACA infarction territory (black arrow) and no high intensity presenting SAH on left frontal convexity. (B) and (C) there is no evidence of acute infarction in DWI and hemorrhagic transformation in SWI. ACA = anterior cerebral artery; SAH = subarachnoid hemorrhage; DWI = diffusion-weighted images; SWI = susceptibility weighted imaging.


Reference

1. Arévalo-Lorido JC, Carretero-Gómez J. Cerebral venous thrombosis with subarachnoid hemorrhage: a case report. Clin Med Res. 2015; 3. 13(1):40–43. PMID: 25380613.
2. Arboix A, García-Eroles L, Sellarés N, Raga A, Oliveres M, Massons J. Infarction in the territory of the anterior cerebral artery: clinical study of 51 patients. BMC Neurol. 2009; 7. 9:30. PMID: 19589132.
Article
3. Cuvinciuc V, Viguier A, Calviere L, Raposo N, Larrue V, Cognard C, et al. Isolated acute nontraumatic cortical subarachnoid hemorrhage. AJNR Am J Neuroradiol. 2010; 9. 31(8):1355–1362. PMID: 20093311.
Article
4. Ducros A, Boukobza M, Porcher R, Sarov M, Valade D, Bousser MG. The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. A prospective series of 67 patients. Brain. 2007; 12. 130(Pt 12):3091–3101. PMID: 18025032.
Article
5. Finelli PF. Cerebral amyloid angiopathy as cause of convexity SAH in elderly. Neurologist. 2010; 1. 16(1):37–40. PMID: 20065795.
Article
6. Geraldes R, Santos C, Canhão P. Atraumatic localized convexity subarachnoid hemorrhage associated with acute carotid artery occlusion. Eur J Neurol. 2011; 2. 18(2):e28–e29. PMID: 20868466.
Article
7. Hentschel S, Toyota B. Intracranial malignant glioma presenting as subarachnoid hemorrhage. Can J Neurol Sci. 2003; 2. 30(1):63–66. PMID: 12619787.
Article
8. Ito H, Uehara K, Matsumoto Y, Hashimoto A, Nagano C, Niimi M, et al. Cilostazol inhibits accumulation of triglyceride in aorta and platelet aggregation in cholesterol-fed rabbits. PLoS One. 2012; 7(6):e39374. PMID: 22761774.
Article
9. Kang SY, Kim JS. Anterior cerebral artery infarction: stroke mechanism and clinical-imaging study in 100 patients. Neurology. 2008; 6. 70(24 Pt 2):2386–2393. PMID: 18541871.
Article
10. Kannoth S, Iyer R, Thomas SV, Furtado SV, Rajesh BJ, Kesavadas C, et al. Intracranial infectious aneurysm: presentation, management and outcome. J Neurol Sci. 2007; 5. 256(1-2):3–9. PMID: 17360002.
Article
11. Kazui S, Sawada T, Naritomi H, Kuriyama Y, Yamaguchi T. Angiographic evaluation of brain infarction limited to the anterior cerebral artery territory. Stroke. 1993; 4. 24(4):549–553. PMID: 8465361.
Article
12. Kumar R, Wijdicks EF, Brown RD Jr, Parisi JE, Hammond CA. Isolated angiitis of the CNS presenting as subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry. 1997; 6. 62(6):649–651. PMID: 9219758.
Article
13. Kumar S, Goddeau RP Jr, Selim MH, Thomas A, Schlaug G, Alhazzani A, et al. Atraumatic convexal subarachnoid hemorrhage: clinical presentation, imaging patterns, and etiologies. Neurology. 2010; 3. 74(11):893–899. PMID: 20231664.
14. Nakajima M, Inatomi Y, Yonehara T, Hirano T, Ando Y. Nontraumatic convexal subarachnoid hemorrhage concomitant with acute ischemic stroke. J Stroke Cerebrovasc Dis. 2014; 7. 23(6):1564–1570. PMID: 24630829.
Article
15. Nakamura K, Ikomi F, Ohhashi T. Cilostazol, an inhibitor of type 3 phosphodiesterase, produces endothelium-independent vasodilation in pressurized rabbit cerebral penetrating arterioles. J Vasc Res. 2006; 43(1):86–94. PMID: 16286783.
Article
16. Nonaka Y, Tsuruma K, Shimazawa M, Yoshimura S, Iwama T, Hara H. Cilostazol protects against hemorrhagic transformation in mice transient focal cerebral ischemia-induced brain damage. Neurosci Lett. 2009; 3. 452(2):156–161. PMID: 19383431.
Article
17. O'Donnell MJ, Hankey GJ, Eikelboom JW. Antiplatelet therapy for secondary prevention of noncardioembolic ischemic stroke: a critical review. Stroke. 2008; 5. 39(5):1638–1646. PMID: 18369175.
18. Rhode V, van Oosterhout A, Mull M, Gilsbach JM. Subarachnoid haemorrhage as initial symptom of multiple brain abscesses. Acta Neurochir (Wien). 2000; 142(2):205–208. PMID: 10795896.
19. Sudo T, Tachibana K, Toga K, Tochizawa S, Inoue Y, Kimura Y, et al. Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity. Biochem Pharmacol. 2000; 2. 59(4):347–356. PMID: 10644042.
Article
20. Sugiura Y, Morikawa T, Takenouchi T, Suematsu M, Kajimura M. Cilostazol strengthens the endothelial barrier of postcapillary venules from the rat mesentery in situ. Phlebology. 2014; 10. 29(9):594–599. PMID: 23858026.
Article
21. Tan L, Margaret B, Zhang JH, Hu R, Yin Y, Cao L, et al. Efficacy and Safety of Cilostazol Therapy in Ischemic Stroke: A Meta-analysis. J Stroke Cerebrovasc Dis. 2015; 5. 24(5):930–938. PMID: 25804574.
Article
22. Wan M, Han C, Xian P, Yang WZ, Li DS, Duan L. Moyamoya disease presenting with subarachnoid hemorrhage: Clinical features and neuroimaging of a case series. Br J Neurosurg. 2015; 29(6):804–810. PMID: 26313681.
Article
23. Wang Y, Pan Y, Zhao X, Li H, Wang D, Johnston SC, et al. Clopidogrel With Aspirin in Acute Minor Stroke or Transient Ischemic Attack (CHANCE) Trial: One-Year Outcomes. Circulation. 2015; 7. 132(1):40–46. PMID: 25957224.
24. Yoon SD, Cho BM, Oh SM, Park SH, Jang IB, Lee JY. Clinical and radiological spectrum of posterior reversible encephalopathy syndrome. J Cerebrovasc Endovasc Neurosurg. 2013; 9. 15(3):206–213. PMID: 24167801.
Article
Full Text Links
  • JCEN
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr