Perinatology.  2016 Sep;27(3):158-161. 10.14734/PN.2016.27.3.158.

Risk Factors Associated Respiratory Insufficiency and Long-term Ventilator Support in Neonates with Omphalocele

• Kim HW
• Shin SH
• Woo HK
• Choi EK
• Song IG
• Jung YH
• Shin SH
• Kim EK
• Kim HS

• KMID: 2355573
• DOI: http://doi.org/10.14734/PN.2016.27.3.158

Abstract

PURPOSE
The objective of this study was to determine factors associated with respiratory insufficiency and long term ventilator-support in newborn with omphalocele.
METHODS
Medical records of neonates with omphalocele in the neonatal intensive care unit (NICU) in Seoul National University Children's Hospital between April 2000 and March 2016 were reviewed retrospectively.
RESULTS
A total of 44 neonates were enrolled. Infants intubated within 24 hours after birth (early intubated group, n=21) and not intubated within 24 hours after birth (late intubated group n=23) were compared. Duration of ventilator care, duration of total parenteral nutrition administration, duration of NICU stay and mortality rate were higher in the early intubated group. The early intubated group had lower gestational age, lower birth weight, lower 1min and 5min Apgar score and higher mortality rate with longer duration of mechanical ventilator support than late intubated group. Persistent pulmonary hypertension and small for gestational age were related to the duration of ventilator support.
CONCLUSION
It is important to predict and prevent of respiratory insufficiency and prolongation of invasive mechanical ventilation in neonates with omphalocele. It is needed to diagnose pulmonary hypertension and respiratory failure after birth in early stages. Further prospective large cohort studies are needed to determine the pathophysiology of respiratory insufficiency and ventilator dependency of neonates with omphalocele reducing morbidity.

Keyword

Omphalocele; Respiratory insufficiency; Pulmonary hypertension

MeSH Terms

Apgar Score
Cohort Studies
Gestational Age
Hernia, Umbilical*
Humans
Hypertension, Pulmonary
Infant
Infant, Low Birth Weight
Infant, Newborn*
Intensive Care, Neonatal
Medical Records
Mortality
Parenteral Nutrition, Total
Parturition
Prospective Studies
Respiration, Artificial
Respiratory Insufficiency*
Retrospective Studies
Risk Factors*
Seoul
Ventilators, Mechanical*

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