J Korean Soc Transplant.  2016 Sep;30(3):120-124. 10.4285/jkstn.2016.30.3.120.

Chronic Rejection after Lung Transplantation

Affiliations
  • 1Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Institute of Chest Diseases, Yonsei University College of Medicine, Seoul, Korea. dobie@yuhs.ac

Abstract

A new classification system for chronic rejection in lung transplantation was recently proposed. Chronic lung allograft dysfunction (CLAD) is regarded as chronic rejection after excluding other causes of allograft dysfunction. CLAD is divided into obstructive CLAD (bronchiolitis obliterans syndrome) and restrictive CLAD (restrictive allograft syndrome). In this review, we will review the latest concepts and current controversies regarding the new CLAD terminology, diagnostic approach, risk factors and possible treatment options.

Keyword

Lung transplantation; Graft rejection; Bronchiolitis obliterans

MeSH Terms

Allografts
Bronchiolitis Obliterans
Classification
Graft Rejection
Lung Transplantation*
Lung*
Risk Factors
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