Ultrasonography.
2016 Oct;35(4):309-317. 10.14366/usg.16006.
Theragnostic ultrasound using microbubbles in the treatment of prostate cancer
- Affiliations
-
- 1Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea. hakjlee@snu.ac.kr
- 2Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.
- 3Program in Nanoscience and Technology, Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.
- KMID: 2354359
- DOI: http://doi.org/10.14366/usg.16006
Abstract
- The use of gas-filled microbubbles in perfusion monitoring as intravascular ultrasound contrast agents has recently become more common. Additionally, microbubbles are employed as carriers of pharmaceutical substances or genes. Microbubbles have great potential to improve the delivery of therapeutic materials into cells and to modify vascular permeability, causing increased extravasation of drugs and drug carriers. Prostate cancer is the most common neoplasm in Europe and America, with an incidence twice to three times that of lung and colorectal cancer. Its incidence is still rising in Asian countries, including Japan and Korea. In this review, we present current strategies regarding the synthesis of microbubbles with targeted ligands on their surfaces, with a focus on prostate cancer.
