Blood Res.  2016 Sep;51(3):204-206. 10.5045/br.2016.51.3.204.

Chronic eosinophilic leukemia with FIP1L1-PDGFRA rearrangement

• Kim TH
• Gu HJ
• Lee WI
• Lee J
• Yoon HJ
• Park TS

• KMID: 2353503
• DOI: http://doi.org/10.5045/br.2016.51.3.204

Abstract

No abstract available.

MeSH Terms

Eosinophils*
Hypereosinophilic Syndrome*

Figure

• 

  Fig. 1 Morphology in a patient of chronic eosinophilic leukemia with a FIP1L1-PDGFRA rearrangement. (A) The number of eosinophils increased (55.7%) in the peripheral blood (PB) smear (Wright-Giemsa, ×1,000). (B) The number of eosinophilic precursors and eosinophils was markedly increased, and equaled up to 36.2% in the bone marrow (BM) aspiration (Wright-Giemsa, ×1,000). Dysplastic eosinophils, including sparse granulation, nuclear hypersegmentation or hyposegmentation are shown in PB smear and BM aspiration (A, B).

• 

  Fig. 2 Fluorescence in situ hybridization (FISH) for the FIP1L1-PDGFRA rearrangement. CHIC2 is labeled in orange, FIP1L1-PDGFRA in green. Loss of orange signal suggests deletion of the 4q12 region on metaphase FISH (A) and interphase FISH (B).

Reference

1. Shin SY, Jung CW, Choi DC, Lee BJ, Kim HJ, Kim SH. Chronic eosinophilic leukemia with a FIP1L1-PDGFRA rearrangement: Two case reports and a review of Korean cases. Blood Res. 2015; 50:58–61. PMID: 25830134.

2. Jeung YJ, Lee JY, Lee GY, Oh MJ, Lee BJ, Choi DC. A case of idiopathic hypereosinophilic syndrome presenting with nocturia and dyspnea. Korean J Asthma Allergy Clin Immunol. 2010; 30:241–245.

3. Kim DW, Shin MG, Yun HK, et al. Incidence and causes of hypereosinophilia (corrected) in the patients of a university hospital. Korean J Lab Med. 2009; 29:185–193. PMID: 19571614.

4. Swerdlow SH, Campo E, Harris NL, editors. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon, France: IARC Press;2008.