J Korean Ophthalmol Soc.  2016 Sep;57(9):1392-1399. 10.3341/jkos.2016.57.9.1392.

Cerebrospinal Fluid Pressure and Trans-lamina Cribrosa Pressure Difference in Open-angle Glaucoma: KNHANES V

• Kim YK
• Tumurbaatar U
• Ohn YH
• Ha SJ
• Park KH

• KMID: 2351869
• DOI: http://doi.org/10.3341/jkos.2016.57.9.1392

Abstract

PURPOSE
To investigate the relationships between estimated cerebrospinal fluid pressure (CSFP) and trans-lamina cribrosa pressure difference (TLCPD) in open-angle glaucoma (OAG) in Korean population.
METHODS
A total of 10,801 eyes were included from the Korean National Health and Nutrition Examination Survey V. All participants (aged 19 years or older) were classified as non-glaucomatous group, OAG suspect group and OAG group. CSFP was calculated as CSFP (mm Hg) = 0.44 body mass index (kg/m²) + 0.16 diastolic blood pressure (mm Hg) - 0.18 age (years) - 1.91. TLCPD was calculated by subtracting CSFP from intraocular pressure.
RESULTS
The mean estimated CSFP was (8.7 ± 3.3 mm Hg vs. 11.6 ± 3.7 mm Hg, 11.2 ± 3.8 mm Hg vs. 11.6 ± 3.7 mm Hg) was lower, and the mean TLCPD (5.7 ± 4.4 mm Hg vs. 2.2 ± 4.4 mm Hg, 3 ± 4.7 mm Hg vs. 2.2 ± 4.4 mm Hg) was higher in the OAG group and in the OAG suspect group than in the non-glaucomatous control group, respectively (p < 0.001). After adjusting relating factor with CSFP and TLCPD using simple linear regression and multivariate analyses, the mean estimated CSFP was distributed lower (p < 0.001; beta: -0.12; B: -2.306; 95% confidence interval [CI]: -2.717, -1.895) in OAG group than in non-glaucomatous group and the mean TLCPD was distributed higher (p < 0.001; beta: 0.099; B: 1.349; 95% CI: 0.977, 1.72; p < 0.001; beta: 0.118; B: 2.776; 95% CI: 2.264, 3.289) in OAG suspect group and in OAG group than in non-glaucomatous group, respectively.
CONCLUSIONS
Estimated CSFP and calculated TLCPD showed essential association with OAG presence. It supports the potential role of low CSFP in the pathogenesis of OAG.

Keyword

Cerebrospinal fluid pressure; Open-angle glaucoma; Trans-lamina cribrosa pressure difference

MeSH Terms

Blood Pressure
Body Mass Index
Cerebrospinal Fluid Pressure*
Cerebrospinal Fluid*
Glaucoma, Open-Angle*
Intraocular Pressure
Linear Models
Multivariate Analysis
Nutrition Surveys

Figure

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  Figure 1. Distribution of estimated cerebrospinal fluid pressure. Estimated cerebrospinal fluid pressure (CSFP) was calculated after adjustment for glaucoma status, sex, log-transformed pulse, total cholesterol, log-transformed triglycerides, corneal refractive power, anterior chamber depth, vertical cup-to-ratio, and intraocular pressure.

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  Figure 2. Distribution of estimated trans-lamina cribrosa pressure difference. Estimated trans-lamina cribrosa pressure difference (TLCPD) was calculated after adjustment for glaucoma status, sex, log-transformed pulse, corneal refractive power, anterior chamber depth, and vertical cup-to-disc ratio.

Reference

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