Clin Mol Hepatol.  2015 Sep;21(3):300-308. 10.3350/cmh.2015.21.3.300.

A case of hepatoblastoma misdiagnosed as combined hepatocellular carcinoma and cholangiocarcinoma in an adult

• Park KW
• Seo CJ
• Yun DY
• Kim MK
• Kim BS
• Han YS
• Oh HK
• Lee CH

• KMID: 2351031
• DOI: http://doi.org/10.3350/cmh.2015.21.3.300

Abstract

Hepatoblastoma usually occurs in children under the age of 2 years, with very few cases reported in adults. We experienced a case of adult hepatoblastoma in a 36-year-old female with chronic hepatitis B . She had experienced sudden onset abdominal pain. Her serum alpha-fetoprotein level was markedly elevated, and abdominal CT showed a 9-cm mass with internal hemorrhage in the right hepatic lobe with hemoperitoneum, so an emergency hepatic central bisectionectomy was performed. The initial histologic examination revealed that the mass mimicked combined hepatocellular carcinoma and cholangiocarcinoma with spindle-cell metaplasia of the cholangiocarcinoma element. Follow-up abdominal CT performed 3 months later showed a 5.5-cm metastatic mass in the left subphrenic area. Laparoscopic splenectomy with mass excision was performed, and hepatoblastoma was confirmed histologically. A histologic re-examination of previously obtained surgical specimens also confirmed the presence of hepatoblastoma. Metastatic hepatoblastoma was found at multiple sites of the abdomen during follow-up, and so chemotherapy with cisplatin, 5-fluorouracil (5-FU), and vincristine was applied, followed by carboplatin and doxorubicin . Despite surgery and postoperative chemotherapy, she died 12 months after symptom onset.

Keyword

Hepatoblastoma; Surgery; Chemotherapy

MeSH Terms

Adult
Carcinoma, Hepatocellular/pathology
Cholangiocarcinoma/pathology
Cisplatin/therapeutic use
Diagnostic Errors
Doxorubicin/therapeutic use
Drug Therapy, Combination
Female
Fluorouracil/therapeutic use
Hepatitis B, Chronic/complications/diagnosis
Hepatoblastoma/drug therapy/*pathology/radiography
Humans
Liver Neoplasms/drug therapy/*pathology/radiography
Tomography, X-Ray Computed
Vincristine/therapeutic use
Cisplatin
Doxorubicin
Fluorouracil
Vincristine