J Korean Radiol Soc.  1979 Jun;15(1):164-171. 10.3348/jkrs.1979.15.1.164.

Experimental studies on the hepatic damage after Co-60 irradiation in rats

• Kim YR
• Kim CS

• KMID: 2349362
• DOI: http://doi.org/10.3348/jkrs.1979.15.1.164

Abstract

In a series of studies to elucidate the direct effect of irradiation on liver, rats we Co-60 irradiated to theright side of liver in a dosage of 600 R. The resuls obtained were as follows. 1. Activities of serum transminase were significantly elevated in the rats 2 and 4 weeks after irradiation, and normalized after 6 weeks. 2. Alkalinephosphatase activities were within normal ranges except for the significant elevation 2 weeks after irradiation.3. The main feature of histologial changes was loss of intracytoplasmic particles followed by vacuolar degeneration of hepatocytes. It appeard markedly 2 weeks after irradiation and normalized after 6 weeks. Veno-occlusive lesion observed in human model was not the main feature in the rats. 4. Depletion of the glycogenparticles in hepatocytes was noticeable 3 days after irradiation, reached to the maximum 2 weeks and returned tobe normal after 6 weeks. 5. Fatty droplets of hepatocytes were seen in a few rats 6 and 8 weeks after irradiation, which were mild and restricted to the periportal region.

MeSH Terms

Animals
Hepatocytes
Humans
Liver
Rats*
Reference Values