J Korean Radiol Soc.  1982 Jun;18(2):200-206. 10.3348/jkrs.1982.18.2.200.

An experimental study on microvascular changes in radiation injury of small intestine

• Kim SH
• Han MC
• Kim CW

• KMID: 2463295
• DOI: http://doi.org/10.3348/jkrs.1982.18.2.200

Abstract

The experimental study was performed to evaluate the microvascular changes in post irradiation injury of small intestine. With a total of 28 rats, 24 rats were irradiated on right upper quadrant of abdomen with a single dose of 2000 rads and each group of 4 rats were followed up in 1,2,4,5,12, and 16 weeks and remaining 4 rats were used for normal control group. Evaluation of the microvascular changes were done by observing both microangiographic and histopathologic findings in groups of each follow-up week. The results were as follows; 1. The main microangiographic findings were stretching and diffuse narrowing of vessels and extravasation of microbarium in post-irradiation 1-4 weeks, and focal narrowing and dilatation, irregular branching pattern and tortuosity of vessesl in in post-irradiation 8-16 weeks. Poor opacification of capillary network was continuously observed in all follow-up period. 2. The degree of vascular tortuosity in microangiography was consistent with the degree of vascular wall thickening in histopathology. 3. It is inferred that results in this experimental study with microangiography can be used as a guide line for further studies of post-irradiation injury of small intestine.