J Korean Radiol Soc.  1996 Jul;35(1):39-45.

Analysis of Prognostic Factors in Patients with Hepatocellular Carcinoma after Transcatheter Hepatic Arterial Chemoembolization(TAE)

Affiliations
  • 1Department of Diagnostic Radiology, College of Medicine, Kyungpook National University Hospital, Korea.

Abstract

PURPOSE
To evaluate long-term survival rates and prognostic factors of patients with hepatocellularcarcinoma after TAE.
MATERIALS AND METHODS
225 patients with hepatocellular carcinoma treated with TAE between January 1988 and December 1994 were studied. Hepatocellular carcinoma was diagnosed either histologically(n=13) orclinically on the basis of findings characteristic for hepatocellular carcinoma obtained using such as diagnostic imaging methods such as ultrasonography, CT, MRI, and angiography as well as on the basis of high serumalpha-fetoprotein level(n=212). TAE was carried out between one and six times(mean, 1.4 time) using a mixture of lipiodol and Adriamycin, together with Gelfoam. Cumulative survival rates from the day of the first TAE were obtained by the Kaplan-Meier method. Parameters likely to influence the prognosis were subjected to univariate analysis using the log-rank test
RESULTS
Cumulative survival rates at the end of the first, second, third, fourth, and fifth year were 55.9%, 32.6%, 21.9%, 17.9%, and 15.0%, respectively. The mean survival time was 727+/-76 days. Several factors, including Child-Pugh classification, Okuda's stage, tumor size, presence of portalvein invasion by tumor, of arterio-portal shunt, and of extra hepatic metastases, catheter selection level, and number of TAE showed significant correlation with the outcome. Degrees of Lipiodol accumulation in a tumor onfollow up CT were also correlated with survival rates.
CONCLUSION
TAE is an effective measure for prolonging the patient's life expectancy and evaluation of prognostic factor is helpful for prognosis and in deciding on the optimal therapeutic modality.

Keyword

Liver neoplasms, angiography; Liver neoplasms, chemotherapeutic infusion; Arteries, therapeutic blockade

MeSH Terms

Angiography
Carcinoma, Hepatocellular*
Catheters
Classification
Doxorubicin
Ethiodized Oil
Fibrinogen
Gelatin Sponge, Absorbable
Humans
Life Expectancy
Magnetic Resonance Imaging
Neoplasm Metastasis
Prognosis
Survival Rate
Ultrasonography
Doxorubicin
Ethiodized Oil
Fibrinogen
Full Text Links
  • JKRS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr