Korean J Med.
2016 Aug;91(1):88-91. 10.3904/kjm.2016.91.1.88.
Fatal Hemophagocytic Lymphohistiocytosis associated with Influenza B
- Affiliations
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- 1Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. wjkim@korea.ac.kr
- 2Department of Laboratory Medicine, Korea University College of Medicine, Seoul, Korea.
- 3Division of Hemato-oncology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
- 4Asia Pacific Influenza Institute, Korea University College of Medicine, Seoul, Korea.
- 5Transgovernmental Enterprise for Pandemic Influenza in Korea, Seoul, Korea.
- KMID: 2345592
- DOI: http://doi.org/10.3904/kjm.2016.91.1.88
Abstract
- Influenza infection may be complicated by various infectious or non-infectious diseases. Among them, hemophagocytic lympho-histiocytosis (HLH) is an uncommon hyperinflammatory syndrome caused by uncontrolled proliferation and activation of macrophages and lymphocytes, and it is often life threatening. A previously healthy male patient was suspected to have HLH after influenza B infection. The diagnosis was established based on clinical diagnostic criteria suggested in the HLH-2004 trial. Despite prompt antiviral therapy, the patient expired on day 19 of hospitalization. Influenza can thus be complicated by HLH. Due to the non-specific manifestations of HLH, clinical suspicion and early diagnosis are important.
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