J Korean Dent Soc Anesthesiol.  2013 Mar;13(1):13-18. 10.17245/jkdsa.2013.13.1.13.

Dental Treatment of Children with CATCH 22 Syndrome: Case Report

• Kim MS
• Lee SE
• Ahn HJ
• Park JH
• Choi SC

• KMID: 2345032
• DOI: http://doi.org/10.17245/jkdsa.2013.13.1.13

Abstract

CATCH 22 syndrome is a one of the most common chromosome microdeletion syndrome with multiple organ anomalies in humans, with an incidence of approximately 1:4,000 to 1:5,000 live births. It is caused by a microdeletion of 1.5 to 3.0 megabases on the long arm of chromosome 22. The phenotypic spectrum of this disorder is wide and various. A 19-year-old patient who showed delayed growth and development (Height; 110 cm, Weight; 18 kg) was referred to our department for the treatment of dental cavities. She was diagnosed as CATCH 22 syndrome in 2004. Physical examination revealed hypertelorism, a short philtrum, thick reflected lips and a small mouth. She underwent cleft palate surgery at 1 year of age and heart valve surgery due to the cardiovascular abnormality at 13 years of age. Convulsive seizures had persisted until 5 years ago but are well controlled at present. Oral examination showed poor oral hygiene, crowding, prolonged retention on #65, 75 and dental cavities on #16, 21, 65, 26, 36, and 46. Cavity treatment and prophylaxis were performed under general anesthesia. Also continuous follow-up checks have been carrying out with the periodic prophylaxis and dental home education. Problems with numerous cavities and gingivitis which can lead to specific risks are common for CATCH 22 syndrome patients. It is therefore of great importance that these patients are referred to foremost physician and dental specialist for the oral care. In addition, preventive treatment targeting the risk of dental cavities and gingivitis is especially important and, as the syndrome involves many different medical problems, the dental treatment should be carried out in collaboration with the patient's physician.

Keyword

CATCH 22 syndrome; DiGeorge syndrome; Chromosome deletion syndrome

MeSH Terms

Anesthesia, General
Arm
Cardiovascular Abnormalities
Child*
Chromosomes, Human, Pair 22
Cleft Palate
Cooperative Behavior
Crowding
Diagnosis, Oral
DiGeorge Syndrome
Education
Follow-Up Studies
Gingivitis
Growth and Development
Heart Valves
Humans
Hypertelorism
Incidence
Lip
Live Birth
Mouth
Oral Hygiene
Physical Examination
Seizures
Specialization
Young Adult