Ann Dermatol.  2016 Aug;28(4):470-478. 10.5021/ad.2016.28.4.470.

Change in Antimicrobial Susceptibility of Skin-Colonizing Staphylococcus aureus in Korean Patients with Atopic Dermatitis during Ten-Year Period

• Park JM
• Jo JH
• Jin H
• Ko HC
• Kim MB
• Kim JM
• Kim DW
• Jang HS
• Kim BS

• KMID: 2344818
• DOI: http://doi.org/10.5021/ad.2016.28.4.470

Abstract

BACKGROUND
A small subset of adolescents atopic dermatitis (AD) tends to persist. This also leads to get more antibiotics exposure with advancing years. Antibiotic resistance has been regarded as a serious problem during Staphylococcus aureus treatment, especially methicillin-resistant S. aureus (MRSA).
OBJECTIVE
It was investigated the S. aureus colonization frequency in the skin lesions and anterior nares of adolescent AD patients and evaluated the changes in S. aureus antimicrobial susceptibility for years.
METHODS
Patients who visited our clinic from September 2003 to August 2005 were classified into group A, and patients who visited from August 2010 to March 2012 were classified into group B. To investigate the differences with regard to patients' age and disease duration, the patients were subdivided into groups according to age. Lesional and nasal specimens were examined.
RESULTS
Among the 295 AD patients, the total S. aureus colonization rate in skin lesions was 66.9% (95/142) for group A and 78.4% (120/153) for group B. No significant changes in the systemic antimicrobial susceptibilities of S. aureus strains isolated from adolescent AD patients were observed during about 10-year period. The increased trend of MRSA isolation in recent adolescent AD outpatients suggest that the community including school could be the source of S. aureus antibiotic resistance and higher fusidic acid resistance rates provides evidence of imprudent topical use.
CONCLUSION
Relatively high MRSA isolation and fusidic acid resistance rates in recent AD patients suggest that the community harbors antibiotic-resistant S. aureus.

Keyword

Anti-bacterial agent; Antimicrobial resistance; Antimicrobial susceptibility; Atopic dermatitis; Staphylococcus aureus

MeSH Terms

Adolescent
Anti-Bacterial Agents
Colon
Dermatitis, Atopic*
Drug Resistance, Microbial
Fusidic Acid
Humans
Methicillin Resistance
Methicillin-Resistant Staphylococcus aureus
Outpatients
Skin
Staphylococcus aureus*
Staphylococcus*
Anti-Bacterial Agents
Fusidic Acid

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