Ann Dermatol.  2016 Aug;28(4):464-469. 10.5021/ad.2016.28.4.464.

Stressful Events and Serum Concentration of Substance P in Acne Patients

• Rokowska-Waluch A
• Pawlaczyk
• Cybulski M
• Å»urawski
• Kaczmarek
• Michalak M
• Mojs E

• KMID: 2344817
• DOI: http://doi.org/10.5021/ad.2016.28.4.464

Abstract

BACKGROUND
Psychological stress is an important factor of acne pathogenesis. Stress related production of hormones, cytokines and neuropeptides may result in the chronic course and exacerbations of the disease.
OBJECTIVE
The aim of the study was to evaluate the relationship between acne severity, intensity of emotional stress and serum concentration of substance P (scSP), to compare the intensity of adversities, psychological stress and scSP in acne patients with healthy controls and to compare coping techniques for stress.
METHODS
The study consisted of 80 patients. Emotional stress was analyzed with the use of social readjustment rating scale, whereas the methods of coping with stress were assessed with the coping inventory for stressful situation questionnaire. The blood concentration of substance P was analyzed by enzyme-linked immunosorbent assay method in a group of 40 patients with acne vulgaris and in control subjects.
RESULTS
There was no statistically significant difference between the severity of acne and the intensity of stress. Acne patients presented a higher average scSP than the controls. No statistically significant correlation was observed between the severity of acne and scSP; however, the intensity of stress correlated with scSP in the control group. The evaluation of methods of coping with stress showed significantly higher rate for the avoidance-oriented coping among acne patients.
CONCLUSION
The number of stressful events is not a factor that determines the severity of acne. The course of the disease may depend on tolerance to stress and methods of coping with stress.

Keyword

Acne vulgaris; Neuropeptides; Stress

MeSH Terms

Acne Vulgaris*
Cytokines
Enzyme-Linked Immunosorbent Assay
Humans
Life Change Events*
Methods
Neuropeptides
Stress, Psychological
Substance P*
Cytokines
Neuropeptides
Substance P

Figure

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  Fig. 1 The comparison of the intensity of stress expressed in life change unit with the use of social readjustment rating scale in acne patients and healthy volunteers.

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  Fig. 2 Clinical state and serum concentration of substance P in investigated subjects.

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  Fig. 3 The comparison of the intensity of stress expressed in life change unit with the use of social readjustment rating scale (SRRS) and substance P serum concentration in the studied group. A, b groups followed by the same letter do not differ statistically significantly.

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  Fig. 4 The avoidance-oriented coping (AOC) with stress assessed with the use of coping inventory for stressful situation (CISS) in studied groups.

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