Korean J Gastroenterol.  2016 Jul;68(1):45-48. 10.4166/kjg.2016.68.1.45.

Solitary Neurofibroma of the Sigmoid Colon Presenting as a Subepithelial Tumor Successfully Removed by Endoscopic Resection

• Lee WJ
• Park SM
• Kim BW
• Kim JS
• Ji JS
• Choi H

• KMID: 2344492
• DOI: http://doi.org/10.4166/kjg.2016.68.1.45

Abstract

Neurofibromas are benign, slow-growing nerve sheath tumors of the peripheral nervous system, arising from Schwann cells, and classically associated with neurofibromatosis type 1 (Nf1, von Recklinghausen's disease). They occur rarely in the gastrointestinal tract as isolated neoplasms, outside the classical clinical feature of neurofibromatosis. We herein present an isolated colonic neurofibroma without any systemic signs of neurofibromatosis. A 59-year-old female came to our hospital for constipation. On physical examination, general appearance showed no definite skin lesions. A subepithelial tumor measuring 0.8 cm was detected at the distal descending colon on colonoscopy. The lesion was removed completely by endoscopic resection. Microscopic examination showed proliferation of spindle cells in the mucosa and infiltration of inflammatory cells. Immunohistochemical staining was positive for S-100 protein. The above morphological and immunohistochemical characteristics were consistent with a diagnosis of a solitary neurofibroma of the sigmoid colon.

Keyword

Neurofibroma; Sigmoid colon; Endoscopic resection

MeSH Terms

Colon
Colon, Descending
Colon, Sigmoid*
Colonoscopy
Constipation
Diagnosis
Female
Gastrointestinal Tract
Humans
Middle Aged
Mucous Membrane
Nerve Sheath Neoplasms
Neurofibroma*
Neurofibromatoses
Neurofibromatosis 1
Peripheral Nervous System
Physical Examination
S100 Proteins
Schwann Cells
Skin
S100 Proteins

Figure

• 

  Fig. 1. Endoscopic resection of the subepithelial tumor. (A) A yellowish subepithelial tumor is noted. (B) Mucosa covering the lesion was removed with a snare. (C) The lesion was removed by submucosal dissection. (D) The lesion was removed completely.

• 

  Fig. 2. Histopathologic finding of the resected tissue. (A) Bundles of spindle cells with elongated and wavy nuclei are noted (H&E, ×200). (B) Immunohistochemical staining for S-100 protein (×200). The spindle cells are stained in red, positive for S-100 protein.

Reference

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