Korean Circ J.  2016 Jul;46(4):536-541. 10.4070/kcj.2016.46.4.536.

Prehypertension and Left Ventricular Diastolic Dysfunction in Middle-Aged Koreans

• Jang SY
• Kim S
• Lee CK
• Cho EJ
• Cho SJ
• Lee SC

• KMID: 2344429
• DOI: http://doi.org/10.4070/kcj.2016.46.4.536

Abstract

BACKGROUND AND OBJECTIVES
Left ventricular diastolic dysfunction is known to be a marker of myocardial damage, in particular myocardial fibrosis resulting from hypertension (HT). However, few studies have shown an association between the grade of diastolic dysfunction and blood pressure classification. We investigated the association between diastolic dysfunction and prehypertension (preHT) in apparently healthy adults who underwent routine health examinations.
SUBJECTS AND METHODS
The study sample included 4261 Koreans, 45 to 64 years of age with no previous history of HT, diabetes mellitus, malignancy, proven coronary artery disease, or valvular heart disease based on echocardiography, who underwent routine health examinations including echocardiography. The subjects were classified into three groups based on resting blood pressure: prehypertensive, hypertensive, and normotensive.
RESULTS
The prevalence of preHT in our study was 42.1%. After adjusting for age, gender, smoking status, alcohol consumption, fasting blood sugar, serum lipid profile, and body mass index, left ventricular diastolic dysfunction grades 1 and 2 were significantly more frequent in subjects with preHT (odds ratio [OR] 1.66 [95% confidence interval {CI} 1.40-1.96] and 1.37 [95% CI 0.95-1.97], respectively). When analyzed according to gender, the increased OR was especially notable in males.
CONCLUSION
Left ventricular diastolic dysfunction appears to be significantly associated with preHT in Korean middle-aged males.

Keyword

Prehypertension; Ventricular dysfunction, left; Echocardiography; Middle-aged

MeSH Terms

Adult
Alcohol Drinking
Blood Glucose
Blood Pressure
Body Mass Index
Classification
Coronary Artery Disease
Diabetes Mellitus
Echocardiography
Fasting
Fibrosis
Heart Valve Diseases
Humans
Hypertension
Male
Prehypertension*
Prevalence
Smoke
Smoking
Ventricular Dysfunction, Left
Blood Glucose
Smoke

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