J Korean Med Sci.  2015 Sep;30(9):1288-1294. 10.3346/jkms.2015.30.9.1288.

The Risk of Colorectal Neoplasia in Patients with Gallbladder Diseases

• Hong SN
• Lee TY
• Yun SC

• KMID: 2344154
• DOI: http://doi.org/10.3346/jkms.2015.30.9.1288

Abstract

Cholecystectomy is associated with an increased risk of colorectal cancer, but little is known about the relationship between gallbladder disease and colorectal adenoma. Gallbladder polyps and colorectal neoplasia (CRN) share several risk factors such as obesity, diabetes and metabolic syndrome, which might account for their association. In this study, we investigated whether asymptomatic patients with gallbladder disease are at increased risk of CRN and identified the factors to their association. The study population consisted of 4,626 consecutive, asymptomatic individuals drawn from a prospective health check-up cohort who underwent both ultrasonography and colonoscopy screening. The prevalence of CRNs in patients with gallbladder polyps or gallstones was significantly higher than that in the control group (32.1% vs. 26.8%; P = 0.032, 35.8% vs. 26.9%; P = 0.020). A multivariate regression analysis showed that gallbladder polyps were an independent risk factor for CRN [adjusted odds ratio (OR): 1.29; 95% confidence interval (CI); 1.03-1.62] whereas gallstones were not (adjusted OR: 1.14; 95% CI: 0.79-1.63). The adjusted OR for the risk of CRN was 1.12 for gallbladder polyps < 5 mm (95% CI, 0.85-1.46) and 1.79 for gallbladder polyps > or = 5 mm (95% CI, 1.15-2.77). The prevalence of CRN increased with increasing polyp size (P trend = 0.022). Our results suggest that colorectal neoplasia is significantly related to gallbladder polyps, especially those > or = 5 mm.

Keyword

Gallbladder; Colorectal Neoplasms; Risk Factors; Korea

MeSH Terms

Adult
Age Distribution
Causality
Colorectal Neoplasms/*diagnosis/*epidemiology
Comorbidity
Female
Gallbladder Diseases/*diagnosis/*epidemiology
Humans
Incidence
Male
Middle Aged
Republic of Korea/epidemiology
Risk Assessment
Sex Distribution

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