J Korean Neurol Assoc.  2008 Feb;26(1):50-54.

A Pathology-proven Case of Schilder's Disease

• Kim BS
• Kim BJ
• Lee KH
• Kim GM

Abstract

Schilder's disease or myelinoclastic diffuse sclerosis (MDS) is a rare variant of multiple sclerosis. We report a 66-year-old woman with progressive motor weakness and diffuse white matter degeneration on MRI, which satisfies the Poser's restrictive criteria of MDS. As previously reported cases of probable Schilder's disease did not meet the criteria correctly, we consider our patient is the first pathology-proven case of MDS in Korea.

Keyword

Diffuse sclerosis; Demyelinating disease; White matter

MeSH Terms

Aged
Demyelinating Diseases
Diffuse Cerebral Sclerosis of Schilder
Female
Humans
Multiple Sclerosis