J Korean Neurol Assoc.
2004 Aug;22(4):402-405.
Complicated Spastic Paraparesis with Thin Corpus Callosum
- Affiliations
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- 1Department of Neurology, Pusan National University College of Medicine, Busan, Korea. qhynbak@pusan.ac.kr
Abstract
- Autosomal recessive hereditary spastic paraparesis (AR-HSP) associated with a thin corpus callosum (TCC) has recently been described in Japan. It is characterized by slowly progressive spastic paraparesis, mental retardation, and thalamic degeneration. We report two unrelated patients with progressive gait disturbance starting in the second decade of life, spastic paraparesis, pes cavus, and mental deterioration. One patient presented with acute psychosis, and the other had visual disturbances with normal tension glaucoma. A brain MRI of both patients showed a thin corpus callosum, and a brain SPECT revealed thalamic hypoperfusion in one patient. This is the first report of spastic paraparesis with a thin corpus callosum in Korea.
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