J Korean Neurol Assoc.  2000 Jul;18(4):465-468.

Dentatorubro-pallidoluysian Atrophy: The Clinical and Molecular Genetic Study of Three Korean Families

• Bae YH
• Im JH
• Lee SA
• Park SS
• Lee MC

Abstract

Dentatorubro-pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder with various clinical phenotypes and has a cytosine-adenine-guanine (CAG) trinucleotide repeat in a gene on chromosome 12. It has been known that trinucleotide repeat disorders show strong inverse correlations between the CAG repeat number and the age of onset and genetic anticipation. The purpose of this study was to investigate whether these observations are applicable to Korean patients. This report involved three Korean families and had on file the history of the 15 affected family mem-bers .Seven of the affected members had the diagnosis of DRPLA which was confirmed by a gene study. We observed inverse correlations between the CAG repeat number and the age of onset and genetic anticipation with high intra- and interfamilial variations. Although our study was in general agreement with previously documented features of DRPLA, some features could not be explained by currently understood pathophysiologic mechanisms.

Keyword

DRPLA, Triple repeats; Neurodegenerative diseases; Programmed cell death

MeSH Terms

Age of Onset
Anticipation, Genetic
Atrophy*
Chromosomes, Human, Pair 12
Diagnosis
Genes, vif
Humans
Molecular Biology*
Neurodegenerative Diseases
Phenotype
Trinucleotide Repeats