J Korean Neurol Assoc.  1994 Sep;12(3):397-409.

Clinical Study of Benign Childhood Epilepsy with Centro-Temporal Spikes

• Yoo YS
• Lim JG
• Yi SD
• Park YC

Abstract

This study was retrospectively undertaken to evaluate clinical manifestations, electroencephalographic findings, response to antiepileptic drugs and prognosis of 80 benign childhood epilepsy with centrotemporal spikes (BCECT) patients seen between 1967 and 1993 and followed up for more than 2 years. The age of onset ranges from 3 to 15 years. In 93 percent of patients, seizures appeared between 4 to 12 year-old, with peak of 5 year-old. The main manifestations of partial seizure were hemifacial spasm (53%) and oropharygeal signs (52%) with hypersalivation, abnormal sensation of mouth, gutteral sounds, swallowing difficulty and feeling of suffocation. The types of seizure consist of partial seizure(66%) and partial seizure with secondary generalization (34%). Distributions of seizure attack were nocturnal sleep (83%), diurnal sleep state(4%) and waking state (13%). The typical EEG findings were slow diaphasic high voltage centrotemporal spikes with unilateral (94%) and bilateral foci(6%) with normal background. In addition to typical EEG findings, there were associated with multifocal independent sharp-waves (8.9%) and generalized sharp-wave discharges (7.8%). BCECT patients were well controlled by antiepileptic drugs and had good prognosis. During the follow-up period (2-17years), we observed that all patient were well adapted to school and society. Seizures did not occur after adolescent period.

MeSH Terms

Adolescent
Age of Onset
Anticonvulsants
Asphyxia
Child
Child, Preschool
Deglutition
Electroencephalography
Epilepsy
Epilepsy, Rolandic*
Follow-Up Studies
Generalization (Psychology)
Hemifacial Spasm
Humans
Mouth
Prognosis
Retrospective Studies
Seizures
Sensation
Sialorrhea
Anticonvulsants