Nutr Res Pract.  2016 Jun;10(3):336-341. 10.4162/nrp.2016.10.3.336.

Association between nutrient intake and thyroid cancer risk in Korean women

• Cho YA
• Lee J
• Kim J

• KMID: 2342137
• DOI: http://doi.org/10.4162/nrp.2016.10.3.336

Abstract

BACKGROUND/OBJECTIVES
The incidence of thyroid cancer has increased in many countries, including Korea. International differences in the incidence of thyroid cancer may indicate a role of diet, but findings from previous studies are inconclusive. Therefore, we aimed to investigate the roles of nutrients in thyroid cancer risk in Korean women.
SUBJECTS/METHODS
We conducted a case-control study comprising 113 cases and 226 age-matched controls. Nutrient intake was assessed using a validated food frequency questionnaire, and the association between nutrient intake and thyroid cancer risk was estimated using a logistic regression model.
RESULTS
We found that high calcium intake was associated with a reduced risk of thyroid cancer (OR [95% CI] = 0.55 [0.35-0.89]). Significant associations were observed among subjects who were older than 50 years, had low BMI, and had low calorie intake. However, other nutrients included in this study did not show any significant associations with thyroid cancer risk.
CONCLUSIONS
This study suggested a possible protective effect of calcium on thyroid cancer risk. Well-designed prospective studies are required to confirm these findings.

Keyword

Thyroid cancer; nutrient; calcium; Korean

MeSH Terms

Calcium
Case-Control Studies
Diet
Female
Humans
Incidence
Korea
Logistic Models
Prospective Studies
Thyroid Gland*
Thyroid Neoplasms*
Calcium

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